Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Ageing represents the single biggest risk factor for development of neurodegenerative
disease. Despite being such long-lived cells, microglia have been relatively understudied for …

Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …

Microglia, the brain's resident myeloid cells, play central roles in brain defense,
homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor …

In 2009, cerebral adrenoleukodystrophy (c-ALD) became the first brain disease to be treated
with lentiviral (LV)-based hematopoietic stem cell gene therapy with the ABCD1 gene in four …

Hypothesis Iron oxide and other ferrite nanoparticles have not yet found widespread
application in the medical field since the translation process faces several big hurdles. The …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5–donor cells is
the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely …

Background Brain-resident microglia have a distinct origin compared to macrophages in
other organs. Under physiological conditions, microglia are maintained by self-renewal from …