Pathophysiology of COVID-19-associated acute kidney injury

M Legrand, S Bell, L Forni, M Joannidis… - Nature Reviews …, 2021 - nature.com
Although respiratory failure and hypoxaemia are the main manifestations of COVID-19,
kidney involvement is also common. Available evidence supports a number of potential …

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

FA Lempp, LB Soriaga, M Montiel-Ruiz, F Benigni… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—
relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically …

Immune determinants of COVID-19 disease presentation and severity

P Brodin - Nature medicine, 2021 - nature.com
Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of
previously healthy individuals, but can cause life-threatening disease or persistent …

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

JA Müller, R Groß, C Conzelmann, J Krüger… - Nature …, 2021 - nature.com
Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical
data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

COVID-19 and diabetes mellitus: from pathophysiology to clinical management

S Lim, JH Bae, HS Kwon, MA Nauck - Nature Reviews Endocrinology, 2021 - nature.com
Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients …

[HTML][HTML] Global pandemics interconnected—obesity, impaired metabolic health and COVID-19

N Stefan, AL Birkenfeld, MB Schulze - Nature Reviews Endocrinology, 2021 - nature.com
Obesity and impaired metabolic health are established risk factors for the non-
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …

COVID-19 and cardiovascular disease: from bench to bedside

MK Chung, DA Zidar, MR Bristow, SJ Cameron… - Circulation …, 2021 - Am Heart Assoc
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential
consequences on the cardiovascular health of millions of people who survive infection …

Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis

A Bayati, R Kumar, V Francis, PS McPherson - Journal of Biological …, 2021 - ASBMB
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
COVID-19, so understanding its biology and infection mechanisms is critical to facing this …