Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

Male infertility impacts millions of couples yet, the etiology of primary infertility remains
largely unknown. A critical element of successful spermatogenesis is maintenance of …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Premature ovarian insufficiency (POI) is the depletion of ovarian function before 40 years of
age due to insufficient oocyte formation or accelerated follicle atresia. Approximately 1–5 …

Purpose The etiology of premature ovarian insufficiency (POI) is heterogeneous, and
genetic factors account for 20–25% of the patients. The primordial follicle pool is determined …

Purpose Patients with reciprocal balanced translocations (RBT) have a risk for recurrent
pregnancy losses (RPL), affected child, and infertility. Currently, genetic counseling is based …