[HTML][HTML] Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

F Luppi, M Kalluri, P Faverio, M Kreuter, G Ferrara - Respiratory Research, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …

Genetic disorders of the surfactant system: focus on adult disease

CHM van Moorsel, JJ van der Vis… - European Respiratory …, 2021 - Eur Respiratory Soc
Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …

[HTML][HTML] Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

S Sakaue, E Yamaguchi, Y Inoue, M Takahashi… - Nature …, 2021 - nature.com
Pulmonary alveolar proteinosis (PAP) is a devastating lung disease caused by abnormal
surfactant homeostasis, with a prevalence of 6–7 cases per million population worldwide …

NKX2. 1 (TTF1) germline mutation associated with pulmonary fibrosis and lung cancer

R Borie, B Funalot, R Epaud, C Delestrain… - ERJ Open …, 2021 - Eur Respiratory Soc
The high prevalence of lung cancer in patients with idiopathic pulmonary fibrosis (3–30%)
has been confirmed by several studies, pointing to specific diagnostic and therapeutic …

Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins

S Morsy, A Morsy - Journal of Molecular Graphics and Modelling, 2021 - Elsevier
Background Autoimmune response after the infection of SARS-COV-2 is evident as more
cases of Guillain Barre syndrome and Kawasaki disease are diagnosed. In this study, we …

[HTML][HTML] Genetic testing for neonatal respiratory disease

LM Nogee, RM Ryan - Children, 2021 - mdpi.com
Genetic mechanisms are now recognized as rare causes of neonatal lung disease. Genes
potentially responsible for neonatal lung disease include those encoding proteins important …

Pulmonary growth abnormalities as etiologies for pediatric pulmonary hypertension

GB Mallory Jr, DR Spielberg… - Pediatric …, 2021 - Wiley Online Library
Pulmonary growth abnormality (PGA) is a common type of diffuse lung disease in infants.
Although the histologic and radiographic features of PGA have been described in the …

[HTML][HTML] Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation

P Prabhudesai, I Khosla, S Kulkarni… - Indian Journal of …, 2021 - ncbi.nlm.nih.gov
A bstract The hereditary form of pulmonary alveolar proteinosis (PAP) is an uncommon
entity. We report a case of PAP due to colony-stimulating factor 2 receptor alpha (CSF2RA) …

[HTML][HTML] Síndrome cerebro-pulmón-tiroides en un recién nacido con deleción 14q12-q21. 1

M Villamil-Osorio, LK Yunis, L Quintero… - Andes …, 2021 - SciELO Chile
Introducción: En recién nacidos con falla respiratoria y enfermedad pulmonar intersticial se
debe realizar el abor daje del Síndrome chILD (children's Interstitial Lung Disease) …

[HTML][HTML] Die idiopathische pulmonale Fibrose jenseits der Lunge: Krankheitsmechanismen verstehen, um Diagnose und Therapie zu verbessern

F Luppi, M Kalluri, P Faverio, M Kreuter… - Kompass …, 2021 - karger.com
Die idiopathische Lungenfibrose (IPF) ist eine chronische progrediente Erkrankung mit einer
geschätzten medianen Überlebensdauer von 3 bis 5 Jahren ab der Diagnose. Sie tritt …