Background: Spatial navigation is the ability to estimate one's position on the basis of
environmental and self-motion cues. Spatial memory is the cognitive substrate underlying …

Mitochondria are double-membraned organelles that exhibit fluidity. They are the main site
of cellular aerobic respiration, providing energy for cell proliferation, migration, and survival; …

Selective vulnerability of different brain regions is seen in many neurodegenerative
disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer's disease …

Objective There is a critical need to establish genetic markers that explain the complex
phenotypes and pathogenicity of ALS. This study identified a polymorphism in the Stathmin …

Four decades ago in 1985, alleles of apolipoprotein E (ApoE) ε2/ε3/ε4 became famous for
explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark …

Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant
part of the population. The majority of AD cases occur in the elderly with a typical age of …

Brain is a fully differentiated organ and is sensitive towards oxidative damage of various
compounds including lipids, proteins, and DNA that occurs during process of normal aging …

Genetic variations at the Apolipoprotein E (ApoE) and microtubule-associated protein tau
(MAPT) loci have been implicated in multiple neurogenerative diseases, but their exact …

Introduction The goal was to investigate effects of APOE‐TOMM40‐'523 haplotypes on
cognitive decline in non‐demented non‐Hispanic Blacks (NHB), and determine whether …

Late-onset Alzheimer disease (LOAD) is highly polygenic, with a heritability estimated
between 40 and 80%, yet risk variants identified in genome-wide studies explain only~ 8 …