[HTML][HTML] CLIP and complementary methods

M Hafner, M Katsantoni, T Köster, J Marks… - Nature Reviews …, 2021 - nature.com
RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

The roles of hnRNP A2/B1 in RNA biology and disease

Y Liu, SL Shi - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …

STREME: accurate and versatile sequence motif discovery

TL Bailey - Bioinformatics, 2021 - academic.oup.com
Motivation Sequence motif discovery algorithms can identify novel sequence patterns that
perform biological functions in DNA, RNA and protein sequences—for example, the binding …

Alternative splicing during mammalian organ development

PV Mazin, P Khaitovich, M Cardoso-Moreira… - Nature …, 2021 - nature.com
Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …

DM3Loc: multi-label mRNA subcellular localization prediction and analysis based on multi-head self-attention mechanism

D Wang, Z Zhang, Y Jiang, Z Mao, D Wang… - Nucleic acids …, 2021 - academic.oup.com
Subcellular localization of messenger RNAs (mRNAs), as a prevalent mechanism, gives
precise and efficient control for the translation process. There is mounting evidence for the …

SEA: simple enrichment analysis of motifs

TL Bailey, CE Grant - BioRxiv, 2021 - biorxiv.org
Motif enrichment algorithms can identify known sequence motifs that are present to a
statistically significant degree in DNA, RNA and protein sequences. Databases of such …

Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures

L Sun, K Xu, W Huang, YT Yang, P Li, L Tang, T Xiong… - Cell research, 2021 - nature.com
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …

XSTREME: Comprehensive motif analysis of biological sequence datasets

CE Grant, TL Bailey - BioRxiv, 2021 - biorxiv.org
XSTREME is a web-based tool for performing comprehensive motif discovery and analysis
in DNA, RNA or protein sequences, as well as in sequences in user-defined alphabets. It is …

Representation learning applications in biological sequence analysis

H Iuchi, T Matsutani, K Yamada, N Iwano… - Computational and …, 2021 - Elsevier
Although remarkable advances have been reported in high-throughput sequencing, the
ability to aptly analyze a substantial amount of rapidly generated biological …

Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition

E Agirre, AJ Oldfield, N Bellora, A Segelle… - Nature …, 2021 - nature.com
Alternative splicing relies on the combinatorial recruitment of splicing regulators to specific
RNA binding sites. Chromatin has been shown to impact this recruitment. However, a limited …