Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Critically ill pediatric patients often require complex medical procedures as well as invasive
testing and monitoring which tend to be painful and anxiety-provoking, necessitating the …

Objectives: Our ex vivo study was designed to determine the sequestration of teicoplanin,
tigecycline, micafungin, meropenem, polymyxin B, caspofungin, cefoperazone sulbactam …

Im Kapitel ECLS (va-ECMO) wird voraussichtlich kein expliziter Hinweis erfolgen, da diese
Therapie in der LL Reg. Nr.: 001-021 nur marginal thematisiert ist und im dessen …

Objectives: There have been few clinical studies of ECMO-related alterations of the PK of
meropenem and conflicting results were reported. This study investigated the …

The aim of this study was to develop a population pharmacokinetics (PK) model for
vancomycin and to evaluate its pharmacodynamic target attainment in adults on …

Background The use of extracorporeal membrane oxygenator (ECMO) support devices are
associated with complications, including bleeding and thrombosis. Unfractionated heparin …

Purpose: Achieving therapeutic levels of phenytoin is critical to its efficacy and safety. Free
serum levels represent pharmacologically active phenytoin due to the high protein binding …

Extracorporeal membrane oxygenation (ECMO) is a mechanical device to support
cardiopulmonary function (Bartlett and Gattinoni 2010). ECMO could stabilize patient's …

2 Article I: An Update on Population Pharmacokinetic Analyses of Vancomycin, Part I: in Adults
Page 40 20 2 Article I: An Update on Population Pharmacokinetic Analyses of Vancomycin, Part …