IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Aging exacerbates neointimal formation by reducing apoptosis of vascular smooth muscle
cells (VSMCs) and induces inflammation within vascular wall. Prep1 is a homeodomain …

Simple Summary Cachexia is a deadly disease that accompanies many different types of
cancers. Animal studies on cachexia have so far mostly been conducted using young mice …

Introduction: Inflammation is a fundamental phenomenon in heart failure, but the prognostic
or therapeutic role of markers such as interleukin-6 (IL-6) has not yet been clarified. The …

ABSTRACT Objective: To 1) assess IL-6 levels in the serum of patients with rheumatoid
arthritis (RA). 2) study IL-6 promoter-174 G> C “single nucleotide polymorphism (SNP)” as …

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular
aspects of neuroinflammation in neurological disorders. The book examines the effect of diet …

Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in
reproductive-age women, indeed multifactorial condition. Cytokines such as TNF-alpha and …

Dysregulated STAT3 signalling is correlated with antibody-mediated autoimmunity and B-
cell neoplasia, but its effect on B cells is underexplored. Here we address this in children …

Metastasis and drug resistance remain the most persistent challenges in the treatment of
cancer today, and account for the vast majority of cancer-related mortality. As a problem of …

abstract Aging is considered a systemic, chronic and low-grade inflammatory state, called
''inflammaging”, which has been contemplated as a risk factor for cancer development and …