Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: what do we know so far?

P Demetter, R Maréchal, F Puleo, M Delhaye… - Frontiers in …, 2021 - frontiersin.org
Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several
other terms have been used to describe its histological appearance. In addition, as …

PD-L1 and notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study

N Silvestris, A Argentiero, O Brunetti… - Expert Opinion on …, 2021 - Taylor & Francis
Background The improved immunological understanding revealed the tumor
microenvironment as an appealing driver to restore the immune response against cancer …

Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles

M Simbolo, S Bersani, C Vicentini… - Expert Opinion on …, 2021 - Taylor & Francis
Background Extrahepatic cholangiocarcinoma (ECC) is classified into two subtypes based
on anatomic origin: distal extrahepatic (DECC) and perihilar (PHCC) cholangiocarcinoma …

Epithelial-mesenchymal transition in undifferentiated carcinoma of the pancreas with and without osteoclast-like giant cells

P Mattiolo, G Fiadone, G Paolino, D Chatterjee… - Virchows Archiv, 2021 - Springer
Undifferentiated carcinoma (UC) and undifferentiated carcinoma with osteoclast-like giant
cells (UCOGC) are peculiar variants of pancreatic ductal adenocarcinoma (PDAC) …

Durable response to PD-1 blockade in a patient with metastatic pancreatic undifferentiated carcinoma with osteoclast-like giant cells

RJ Besaw, AR Terra, GL Malvar, TR Chapman… - Journal of the National …, 2021 - jnccn.org
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a
rare and potentially aggressive variant of pancreatic ductal adenocarcinoma. Data on this …

Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: a review and case report analysis

A Kharkhach, T Bouhout, B Serji… - Journal of Gastrointestinal …, 2021 - Springer
Discussion UPCOCs are rare tumors that were described only in historical case reports.
These tumors account for 2–7% of all pancreatic cancers and 11% of all undifferentiated …

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a challenging cancer with new horizons?

C Luchini - Virchows Archiv, 2021 - Springer
Histologically, UCOGS are heterogeneous, hypercellular tumors composed of three types of
cells:(1) histiocytes, which are mononuclear and usually located adjacent to …

Osteoclast-like giant cell tumors of the pancreas: clinical characteristics, genetic testing, and treatment modalities

BE Ueberroth, AJ Liu, RP Graham, TS Bekaii-Saab… - Pancreas, 2021 - journals.lww.com
Objectives This study sought to better characterize patient characteristics, treatment options,
and outcomes for osteoclast-like giant cell carcinoma of the pancreas, a rare subtype of …