Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

Therapy resistance is a major problem when treating cancer patients as cancer cells
develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Anthranilic acid and its analogues present a privileged profile as pharmacophores for the
rational development of pharmaceuticals deliberated for managing the pathophysiology and …

The hedgehog (SHH) signaling pathway is primarily involved in embryonic gut development,
smooth muscle differentiation, cell proliferation, adult tissue homeostasis, tissue repair …

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays
an essential role in controlling cell specification and proliferation, survival factors, and tissue …

Hedgehog (Hh) signaling is a classic morphogen in controlling embryonic development and
tissue repairing. Aberrant activation of Hh signaling has been well documented in liver …

The evolving concept that cancer stem cells (CSCs) are the driving element in cancer
development, evolution and heterogeneity, has overridden the previous model of a tumor …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population
of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some …