The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …

It is commonly recognized in the field that cancer cells exhibit changes in the size and shape
of their nuclei. These features often serve as important biomarkers in the diagnosis and …

Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible
for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that …

The nucleus, central to cellular activity, relies on both direct mechanical input as well as its
molecular transducers to sense external stimuli and respond by regulating intra-nuclear …

Skeletal muscle demonstrates a high degree of adaptability in response to changes in
mechanical input. The phenotypic transformation in response to mechanical cues includes …

Nuclear envelope proteins play an important role in regulating nuclear size and structure in
cancer. Altered expression of nuclear lamins are found in many cancers and its expression …

Emerin is the inner nuclear membrane protein involved in maintaining the mechanical
integrity of the nuclear membrane. Mutations in EMD encoding emerin cause Emery …

Emerin is an integral membrane protein of the nuclear envelope that participates in the
maintenance of nuclear shape. When mutated or absent, emerin causes X-linked Emery …

Over the last few decades great advances have been made in our understanding of gene
expression and the human genome. In 2003 the human genome was sequenced for the first …

L'entrée en mitose est initiée par le complexe cycline B–Cdk1. La phosphorylation de ses
substrats déclenche des transformations incluant la condensation des chromosomes, le bris …