Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy
NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
Precise subcellular organelle targeting for boosting endogenous‐stimuli‐mediated tumor therapy
W Zhen, S An, S Wang, W Hu, Y Li, X Jiang… - Advanced …, 2021 - Wiley Online Library
Though numerous external‐stimuli‐triggered tumor therapies, including phototherapy,
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …
Highly stable silica-coated bismuth nanoparticles deliver tumor microenvironment-responsive prodrugs to enhance tumor-specific photoradiotherapy
H Xiang, Y Wu, X Zhu, M She, Q An… - Journal of the …, 2021 - ACS Publications
Radiosensitizers are agents capable of amplifying injury to tumor tissues by enhancing DNA
damage and fortifying production of radical oxygen species (ROS). The use of such …
damage and fortifying production of radical oxygen species (ROS). The use of such …
[HTML][HTML] Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system
X Su, Y Cao, Y Liu, B Ouyang, B Ning, Y Wang… - Materials Today Bio, 2021 - Elsevier
Ferroptosis has received ever-increasing attention due to its unparalleled mechanism in
eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides …
eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides …
An Endoplasmic Reticulum Specific Pro‐amplifier of Reactive Oxygen Species in Cancer Cells
HG Xu, M Schikora, M Sisa, S Daum… - Angewandte Chemie …, 2021 - Wiley Online Library
The folding and export of proteins and hydrolysis of unfolded proteins are disbalanced in the
endoplasmic reticulum (ER) of cancer cells, leading to so‐called ER stress. Agents further …
endoplasmic reticulum (ER) of cancer cells, leading to so‐called ER stress. Agents further …
In vitro and in vivo of triphenylamine-appended fluorescent half-sandwich iridium (iii) thiosemicarbazones antitumor complexes
M Shao, M Yao, X Liu, C Gao, W Liu, J Guo… - Inorganic …, 2021 - ACS Publications
Half-sandwiched structure iridium (III) complexes appear to be an attractive organometallic
antitumor agents in recent years. Here, four triphenylamine-modified fluorescent half …
antitumor agents in recent years. Here, four triphenylamine-modified fluorescent half …
Differential responses to bioink-induced oxidative stress in endothelial cells and fibroblasts
H Genç, J Hazur, E Karakaya, B Dietel, F Bider… - International Journal of …, 2021 - mdpi.com
A hydrogel system based on oxidized alginate covalently crosslinked with gelatin (ADA-
GEL) has been utilized for different biofabrication approaches to design constructs, in which …
GEL) has been utilized for different biofabrication approaches to design constructs, in which …
Time-programmed activation of dual polyprodrugs for synergistic cascade oxidation-chemotherapy
Y Liu, M Jiang, Y Tu, K Wang, Q Zong, Y Yuan - Biomaterials, 2021 - Elsevier
Combination therapy using multiple drugs with time-programmed administration is
promising for enhanced cancer treatment. However, it is still challenging to achieve time …
promising for enhanced cancer treatment. However, it is still challenging to achieve time …
Photo-triggered nucleus targeting for cancer drug delivery
Here, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting
ability under a spatiotemporal control. The nanoparticles were constructed through self …
ability under a spatiotemporal control. The nanoparticles were constructed through self …
Mannose modified zwitterionic polyester-conjugated second near-infrared organic fluorophore for targeted photothermal therapy
J Li, L Zheng, C Li, Y Xiao, J Liu, S Wu… - Biomaterials Science, 2021 - pubs.rsc.org
Cancer resistance has been the huge challenge to clinical treatment. A photothermal
therapy of second near-infrared (NIR-II) organic dye small molecule has been used to …
therapy of second near-infrared (NIR-II) organic dye small molecule has been used to …