[HTML][HTML] Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

[HTML][HTML] The cholinergic system, the adrenergic system and the neuropathology of Alzheimer's disease

RA Bekdash - International Journal of Molecular Sciences, 2021 - mdpi.com
Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …

[HTML][HTML] Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome …

N Sandoval-Villegas, W Nurieva, M Amberger… - International journal of …, 2021 - mdpi.com
Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use

SI Gavrilova, A Alvarez - Medicinal Research Reviews, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurocognitive disorder and a global health
problem. The prevalence of AD is growing dramatically, especially in low‐and middle …

[HTML][HTML] Gene therapy in epilepsy

L Zhang, Y Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Gene therapy may constitute a promising alternative to conventional pharmacological tools
and surgeries for epilepsy. For primary epilepsy, a single variant leading to a significant …

[HTML][HTML] Bridging scales in alzheimer's disease: Biological framework for brain simulation with the virtual brain

L Stefanovski, JM Meier, RK Pai, P Triebkorn… - Frontiers in …, 2021 - frontiersin.org
Despite the acceleration of knowledge and data accumulation in neuroscience over the last
years, the highly prevalent neurodegenerative disease of AD remains a growing problem …

[HTML][HTML] Nerve growth factor biodelivery: a limiting step in moving toward extensive clinical application?

G Alastra, L Aloe, VA Baldassarro, L Calzà… - Frontiers in …, 2021 - frontiersin.org
Nerve growth factor (NGF) was the first-discovered member of the neurotrophin family, a
class of bioactive molecules which exerts powerful biological effects on the CNS and other …

[HTML][HTML] Topical delivery of nerve growth factor for treatment of ocular and brain disorders

G Eftimiadi, M Soligo, L Manni, D Di Giuda… - Neural Regeneration …, 2021 - journals.lww.com
Neurotrophins are a family of proteins that support neuronal proliferation, survival, and
differentiation in the central and peripheral nervous systems, and are regulators of neuronal …

[HTML][HTML] Intranasal delivery of nerve growth factor in neurodegenerative diseases and neurotrauma

L Manni, G Conti, A Chiaretti, M Soligo - Frontiers in pharmacology, 2021 - frontiersin.org
Since the 1980s, the development of a pharmacology based on nerve growth factor (NGF)
has been postulated for the therapy of Alzheimer's disease (AD). This hypothesis was based …

[HTML][HTML] CSF and plasma cholinergic markers in patients with cognitive impairment

A Karami, T Darreh-Shori, M Schultzberg… - Frontiers in Aging …, 2021 - frontiersin.org
Introduction Alzheimer's disease (AD) is the most prevalent form of dementia with symptoms
of deteriorating cognitive functions and memory loss, partially as a result of a decrease in …