Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro

SR Moses, JJ Adorno, AF Palmer… - American Journal of …, 2021 - journals.physiology.org
To understand how the microvasculature grows and remodels, researchers require
reproducible systems that emulate the function of living tissue. Innovative contributions …

Review of OCT angiography findings in diabetic retinopathy: insights and perspectives

J Moir, S Khanna, D Skondra - International Journal of Translational …, 2021 - mdpi.com
Diabetes mellitus (DM), a disorder rapidly growing in prevalence, is linked to the retinal
microvasculature complication diabetic retinopathy (DR). As one of the leading global …

Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

BC Rothwell, NF Kirkby, MJ Merchant… - Physics in Medicine …, 2021 - iopscience.iop.org
There has been a recent revival of interest in the FLASH effect, after experiments have
shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no …

A mesoscale computational model for microvascular oxygen transfer

L Possenti, A Cicchetti, R Rosati, D Cerroni… - Annals of Biomedical …, 2021 - Springer
We address a mathematical model for oxygen transfer in the microcirculation. The model
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …

The capillary fascicle in skeletal muscle: Structural and functional physiology of RBC distribution in capillary networks

AA Mendelson, S Milkovich, T Hunter… - The Journal of …, 2021 - Wiley Online Library
Key points The capillary module, consisting of parallel capillaries from arteriole to venule, is
classically considered as the building block of complex capillary networks. In skeletal …

Morphological and functional relationship between OCTA and FA/ICGA quantitative features in AMD-related macular neovascularization

A Arrigo, E Aragona, A Bordato, A Amato… - Frontiers in …, 2021 - frontiersin.org
Background: The aim was to study the relationship between quantitative information
provided by optical coherence tomography (OCT) angiography (OCTA) and conventional …

Do skeletal muscle motor units and microvascular units align to help match blood flow to metabolic demand?

CL Murrant, NM Fletcher, EJH Fitzpatrick… - European journal of …, 2021 - Springer
Purpose We explore the motor unit recruitment and control of perfusion of microvascular
units in skeletal muscle to determine whether they coordinate to match blood flow to …

Regenerated microvascular networks in ischemic skeletal muscle

H Yin, JM Arpino, JJ Lee, JG Pickering - Frontiers in Physiology, 2021 - frontiersin.org
Skeletal muscle is the largest organ in humans. The viability and performance of this
metabolically demanding organ are exquisitely dependent on the integrity of its …

Quantitative optical coherence tomography angiography parameter variations after treatment of macular neovascularization secondary to age-related macular …

A Arrigo, E Aragona, A Bordato, A Amato, F Borghesan… - Retina, 2021 - journals.lww.com
Purpose: Macular neovascularization (MNV) secondary to age-related macular
degeneration can be characterized by quantitative optical coherence tomography …

A two-compartment model of oxygen transport in skeletal muscle using continuously distributed capillaries

KC Afas, R Vijay, D Goldman - Mathematical Biosciences, 2021 - Elsevier
For future application to studying regulation of microvascular oxygen delivery, a model is
developed for O 2 transport within an idealized volume of tissue, that is perfused by a …