Introduction: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more
pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and …

Children often present to the pediatric endocrinologist because their height or growth pattern
raises concerns about a possible underlying health problem, about their psychosocial …

Pituitary blastoma (PitB) has recently been identified as a rare and potentially lethal pediatric
intracranial tumor. All cases that have been studied molecularly possess at least one …

The relationship between congenital defects of the brain and facial anomalies was proven.
The Hedgehog signaling pathway plays a fundamental role in normal craniofacial …

Introduction: According to recent literature, somatic mutations in the ubiquitin-specific
protease 8 (USP8) gene are the most common changes in patients with Cushing's disease …

利用候选基因法和全基因组关联分析法等方法能准确筛选出绵羊生长性状相关的关键基因,
挖掘关键基因相关遗传变异位点作为DNA 标记进行应用, 以提高选择准确性, 加快遗传进展 …

Targeted oncogenesis is the process of driving tumor formation by engineering transgenic
mice that express an oncogene under the control of a cell-type specific promoter. Such …

Background Hypothyroidism is a common endocrine disorder characterized by a deficiency
of thyroid hormones less than the normal levels. Recent research studies identified the …

In dairy cattle, even though both bulls and cows contribute to reproductive efficiency, the bull
fertility has been given very less consideration as compared to females. Direct selection for …

Objetivo: O hipopituitarismo congênito é a deficiência de um ou mais hormônios
hipofisários, sendo muito comum a deficiência do hormônio de crescimento (GH). Pode …