Cannabinoids in the landscape of cancer
N Mangal, S Erridge, N Habib, A Sadanandam… - Journal of cancer …, 2021 - Springer
Introduction Cannabinoids are a group of terpenophenolic compounds derived from the
Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal …
Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal …
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases
F Lachkar, P Ferré, F Foufelle… - American Journal of …, 2021 - journals.physiology.org
Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded
as biologically inactive. They are metabolic intermediates of the de novo sphingolipid …
as biologically inactive. They are metabolic intermediates of the de novo sphingolipid …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells
P Muñoz-Guardiola, J Casas, E Megías-Roda, S Solé… - Autophagy, 2021 - Taylor & Francis
ABSTRACT ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is
currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and …
currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and …
Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis
YQ Di, XL Han, XL Kang, D Wang, CH Chen, JX Wang… - Autophagy, 2021 - Taylor & Francis
ABSTRACT CTSD/CathD/CATD (cathepsin D) is a lysosomal aspartic protease. A
distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via …
distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via …
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide-and loperamide-induced glioma cell death
Increasing evidence suggests that induction of lethal macroautophagy/autophagy carries
potential significance for the treatment of glioblastoma (GBM). In continuation of previous …
potential significance for the treatment of glioblastoma (GBM). In continuation of previous …
Ceramide metabolism and Parkinson's disease—therapeutic targets
A Custodia, M Aramburu-Núñez, C Correa-Paz… - Biomolecules, 2021 - mdpi.com
Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …
being the precursor of complex sphingolipids, ceramides can act as second messengers …
Pharmacological and toxicological effects of phytocannabinoids and recreational synthetic cannabinoids: Increasing risk of public health
Synthetic Cannabinoids (CBs) are a novel class of psychoactive substances that have
rapidly evolved around the world with the addition of diverse structural modifications to …
rapidly evolved around the world with the addition of diverse structural modifications to …
Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor …
A Ellert-Miklaszewska, IA Ciechomska, B Kaminska - Cancers, 2021 - mdpi.com
Simple Summary Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic
defects in TP53 and PTEN tumor suppressor genes, which render tumors refractory to …
defects in TP53 and PTEN tumor suppressor genes, which render tumors refractory to …
Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from Cannabis sativa L. Promising Compounds?
Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids
that are receiving renewed interest due to their diverse pharmacologic activities. Indeed …
that are receiving renewed interest due to their diverse pharmacologic activities. Indeed …