Indoxyl-sulfate-induced redox imbalance in chronic kidney disease

CL Lu, CM Zheng, KC Lu, MT Liao, KL Wu, MC Ma - Antioxidants, 2021 - mdpi.com
The accumulation of the uremic toxin indoxyl sulfate (IS) induces target organ damage in
chronic kidney disease (CKD) patients, and causes complications including cardiovascular …

Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK …

M Sugimoto, R Ko, H Goshima, A Koike, M Shibano… - Neurotoxicology, 2021 - Elsevier
Formononetin is an isoflavone, found in herbs like Trifolium pratense, which executes a
variety of physiological activities including anti-neurodegenerative effect. However, the …

A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis

A Malek Mahdavi, Z Javadivala - Amino Acids, 2021 - Springer
Due to the undesirable effects of conventional medical therapies prescribed for rheumatoid
arthritis (RA), complementary therapies, especially nutritional agents, have recently gained …

Heme oxygenase-1 inhibition potentiates the effects of nab-paclitaxel-gemcitabine and modulates the tumor microenvironment in pancreatic ductal adenocarcinoma

IM Ahmad, AJ Dafferner, KA O'connell, K Mehla… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
malignancies. Chemotherapy has had limited success in extending the life span of patients …

Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis

L Zhou, J Chang, W Zhao, Y Gao - Pesticide Biochemistry and Physiology, 2021 - Elsevier
Cypermethrin, a type II pyrethroid pesticide, is one of the most widely used pesticides in
agricultural and in household settings. The toxic effects of cypermethrin are a matter of …

Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

K Bukowska-Strakova, J Włodek, E Pitera… - International Journal of …, 2021 - mdpi.com
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased
remarkably over the last decades, the therapy resistance and toxicity are still the major …

Targeting endogenous gaseous signaling molecules as novel host-directed therapies against tuberculosis infection

K Gautam, S Negi, V Saini - Free Radical Research, 2021 - Taylor & Francis
Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis
which is a major cause of morbidity and mortality worldwide. Due to the complexity of …

Forsythia fruit prevents fulminant hepatitis in mice and ameliorates inflammation in murine macrophages

YH Jeong, YH Hwang, TI Kim, YC Oh, JY Ma - Nutrients, 2021 - mdpi.com
Forsythia Fruit (FF), the fruit of Forsythia suspensa, has been used since ancient times as an
herbal medication in East Asia to treat inflammation, gonorrhea, and pharyngitis. However …

Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells

TN Pitanga, SS Santana, DL Zanette, CC Guarda… - Inflammation …, 2021 - Springer
Objective and design This study tested the hypothesis that sickle red blood cell (SS-RBC)
can induce inflammasome NLRP3 components gene expression in peripheral blood …

Do genetic variants modify the effect of smoking on risk of preeclampsia in pregnancy?

AE Bauer, CL Avery, M Shi… - American journal of …, 2021 - thieme-connect.com
Objective Maternal smoking is associated with as much as a 50% reduced risk of
preeclampsia, despite increasing risk of other poor pregnancy outcomes that often co-occur …