[HTML][HTML] Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?

A Dalhoff - Infection, 2021 - Springer
Background Selective toxicity antibacteribiotics is considered to be due to interactions with
targets either being unique to bacteria or being characterized by a dichotomy between pro …

[HTML][HTML] NR4A3: a key nuclear receptor in vascular biology, cardiovascular remodeling, and beyond

J Martínez-González, L Cañes, J Alonso… - International journal of …, 2021 - mdpi.com
The mechanisms committed in the activation and response of vascular and inflammatory
immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such …

High NOR-1 (neuron-derived orphan receptor 1) expression strengthens the vascular wall response to angiotensin II leading to aneurysm formation in mice

L Cañes, I Martí-Pàmies, C Ballester-Servera… - …, 2021 - Am Heart Assoc
No drug therapy has shown to limit abdominal aortic aneurysm (AAA) growth or rupture, and
the understanding of the disease biology is incomplete; whereby, one challenge of vascular …

The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension

S Hadzic, CY Wu, M Gredic… - … of Physiology-Lung …, 2021 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is a major cause of death and a still
incurable disease, comprising emphysema and chronic bronchitis. In addition to airflow …

The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial

NO Mansour, MA Shama… - Therapeutic Advances in …, 2021 - journals.sagepub.com
Objective: We aimed to examine the effect of doxycycline on serum levels of neuron-specific
enolase (NSE), a marker of neuronal damage in traumatic brain injury (TBI) patients …

An overview of investigational and experimental drug treatment strategies for Marfan syndrome

V Deleeuw, A De Clercq, J De Backer… - Journal of experimental …, 2021 - Taylor & Francis
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by pathogenic
variants in the gene coding for the extracellular matrix protein fibrillin-1. While the disease …

[HTML][HTML] Purinergic signaling in controlling macrophage and T cell functions during atherosclerosis development

D Ferrari, A La Sala, D Milani, C Celeghini… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a hardening and narrowing of arteries causing a reduction of blood flow. It
is a leading cause of death in industrialized countries as it causes heart attacks, strokes, and …

Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

AJM Chaves Filho, M Mottin, MVR Soares… - Behavioural …, 2021 - journals.lww.com
Major mental disorders, such as schizophrenia, bipolar disorder, and major depressive
disorder, represent the leading cause of disability worldwide. Nevertheless, the current …

[HTML][HTML] Treadmill exercise ameliorates impairment of spatial learning memory in pups born to old and obese mother rats

SH Kim, IG Ko, JJ Jin, L Hwang… - Journal of exercise …, 2021 - ncbi.nlm.nih.gov
Memory state of rat pups born to old and obese mother rats and the effect of a treadmill
running of mother rats on the memory of rat pups were studied. The radial 8-arm maze test …

Current pharmacological management of aortic aneurysm

B Xiang, S Zhu, J Li, H Lai, C Wang… - Journal of Cardiovascular …, 2021 - journals.lww.com
Aortic aneurysm (AA) remains one of the primary causes of death worldwide. Of the major
treatments, prophylactic operative repair is used for AA to avoid potential aortic dissection or …