Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

A Conforti, I Di Cola, V Pavlych, P Ruscitti… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the
systemic inflammatory process may involve other tissues and organs. Many extra-articular …

[HTML][HTML] Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

[HTML][HTML] Lung cancer is also a hereditary disease

PR Benusiglio, V Fallet, M Sanchis-Borja… - European …, 2021 - Eur Respiratory Soc
Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

AE John, C Joseph, G Jenkins… - Immunological reviews, 2021 - Wiley Online Library
The COVID‐19 pandemic rapidly spread around the world following the first reports in
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …

The interplay of the genetic architecture, aging, and environmental factors in the pathogenesis of idiopathic pulmonary fibrosis

A Pardo, M Selman - American journal of respiratory cell and …, 2021 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease of indeterminate
etiology and limited therapeutic options. The initiation, development, and progression of IPF …

[HTML][HTML] Molecular biomarkers in idiopathic pulmonary fibrosis: state of the art and future directions

A Stainer, P Faverio, S Busnelli, M Catalano… - International Journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF), the most lethal form of interstitial pneumonia of unknown
cause, is associated with a specific radiological and histopathological pattern (the so-called …

[HTML][HTML] Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

KD Alysandratos, SJ Russo, A Petcherski, EP Taddeo… - Cell reports, 2021 - cell.com
Alveolar epithelial type 2 cell (AEC2) dysfunction is implicated in the pathogenesis of adult
and pediatric interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF); …

Targeting alveolar repair in idiopathic pulmonary fibrosis

VA Ptasinski, J Stegmayr, MG Belvisi… - American journal of …, 2021 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic
options. Current evidence suggests that IPF may be initiated by repeated epithelial injuries …

[HTML][HTML] Evaluation of correlations between genetic variants and high-resolution computed tomography patterns in idiopathic pulmonary fibrosis

E Baratella, B Ruaro, F Giudici, B Wade… - Diagnostics, 2021 - mdpi.com
Background. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung
disease (ILD). This prospective observational study aimed at the evaluation of any …

Genetic disorders of the surfactant system: focus on adult disease

CHM van Moorsel, JJ van der Vis… - European Respiratory …, 2021 - Eur Respiratory Soc
Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …