INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

Summary p53 may operate as an intracellular antiviral defense mechanism. To circumvent it,
SARS viruses adopt a kidnap and exploit strategy also shared by several viruses with …

The tumor-suppressor protein p53 is mutated in approximately half of all cancers, whereas
the p53 signaling network is perturbed in almost all cancers. In response to different stress …

The repression of repetitive elements is an important facet of p53's function as a guardian of
the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the …

Background: Reversal of CD8 T-cell exhaustion was considered a major antitumor
mechanism of anti-programmed cell death-1 (PD-1)/anti-programmed death ligand-1 (PD …

Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …

WSX1, a receptor subunit for IL-27, is widely expressed in immune cells and closely
involved in immune response, but its function in nonimmune cells remains unknown. Here …

Background MDM2/MDMX proteins are frequently elevated in hormone receptor-positive
(ER+) breast cancer. We sought to determine the antitumor efficacy of the combination of …

Tyrosine kinase inhibitors (TKI) play a pivotal role in the treatment of non-small-cell lung
cancer (NSCLC) with mutations in epidermal growth factor receptor (EGFR) and …

Bioflavonoids are the largest group of plant-derived polyphenolic compounds with diverse
biological potential and have also been proven efficacious in the treatment of Severe Acute …