Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an
annual increase of 5 million cases. Most AF patients have an established form of an atrial …

Cerebrovascular disease is the most common life-threatening and debilitating condition that
often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II …

Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …

Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems,
and diabetes is an independent risk factor for AF. However, the mechanism (s) underlying …

Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac
arrhythmia, are urgently needed, the development of which requires improved …

Abstract Coronavirus disease-19 (COVID-19) pandemic is associated with high morbidity
and mortality. COVID-19, which is caused by the Severe Acute Respiratory Syndrome …

Hormones are potent endo-, para-, and autocrine endogenous regulators of the function of
multiple organs, including the heart. Endocrine dysfunction promotes a number of …

Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the
result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII …

Although well documented drug therapies are available for the management of ventricular
hypertrophy (VH) and heart failure (HF), most patients nonetheless experience a downhill …

Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of
glucose, glucose metabolites, and other reducing sugars with different substrates, such as …