Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases
E Kulikowski, BD Rakai… - Medicinal research …, 2021 - Wiley Online Library
Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …
from the traditional course of drug development. These drugs are simultaneously being …
Scanning protein surfaces with DNA‐encoded libraries
VBK Kunig, M Potowski, M Klika Škopić… - …, 2021 - Wiley Online Library
Understanding the ligandability of a target protein, defined as the capability of a protein to
bind drug‐like compounds on any site, can give important stimuli to drug‐development …
bind drug‐like compounds on any site, can give important stimuli to drug‐development …
Recent Advances on the Selection Methods of DNA‐Encoded Libraries
Y Huang, X Li - ChemBioChem, 2021 - Wiley Online Library
DNA‐encoded libraries (DEL) have come of age and become a major technology platform
for ligand discovery in both academia and the pharmaceutical industry. Technological …
for ligand discovery in both academia and the pharmaceutical industry. Technological …
[HTML][HTML] Dual Bcl-XL/Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy
JP Daguer, A Gonse, Y Shchukin… - Bioorganic & Medicinal …, 2021 - Elsevier
Abstract A dual Bcl-X L/Bcl-2 inhibitor was discovered from DNA-encoded libraries using a
two steps process. In the first step, DNA was used to pair PNA-encoded fragments …
two steps process. In the first step, DNA was used to pair PNA-encoded fragments …