Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulated
through mitogen-activated protein kinase (MAPK) signaling or genetic alteration across …

Neural stem/progenitor cells (NSPCs) persist over the lifespan while encountering constant
challenges from age or injury related brain environmental changes like elevated oxidative …

New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult
hippocampus to support ongoing learning and memory formation. To generate functional …

Capicua (Cic), a transcriptional repressor frequently mutated in brain cancer
oligodendroglioma, is highly expressed in adult neurons. However, its function in the …

Background The transcription factor capicua (CIC) regulates mammalian development and
homeostasis. Growing evidence shows that CIC suppresses various human cancers by …

Adult diffuse gliomas are deadly tumours that are characterized by extensive molecular (eg
genetic, transcriptomic, epigenetic, proteomic) and cellular (eg microenvironmental) …

[eng] The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key
functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In …