Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …

Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-
binding protein, is a primary component of insoluble aggregates associated with several …

Alterations in the components [nucleoporins (Nups)] and function of the nuclear pore
complex (NPC) have been implicated as contributors to the pathogenesis of genetic forms of …

Chronic cellular stress associated with neurodegenerative disease can result in the
persistence of stress granule (SG) structures, membraneless organelles that form in …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by selective, early degeneration of motor neurons in the brain and spinal cord …

Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously
expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid …

Neurodegenerative diseases are challenging for systems biology because of the lack of
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …

Objective There is a critical need to establish genetic markers that explain the complex
phenotypes and pathogenicity of ALS. This study identified a polymorphism in the Stathmin …

Gene editing technologies hold great potential to enhance our ability to model inheritable
neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the progressive degeneration of motor neurons. The causative pathogenic mechanisms in …