Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly
used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of …

Ten indole and oxindole alkaloids (1–10) were isolated from the freshly collected leaves of
Malaysian Mitragyna speciosa (Kratom). The chemical structures of these compounds were …

Mitragynine and 7-hydroxymitragynine (7OH) are the major alkaloids mediating the
biological actions of the psychoactive plant kratom. To investigate the structure–activity …

In this paper, an efficient synthesis of 3-spirooxindole 3H-indoles through the coupling and
spirocyclization of N-aryl amidines with diazo oxindoles is presented. Mechanistically, the …

Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and
antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 …

Mitragynine is one of the dominant alkaloids present in Mitragyna speciosa. The compound
possesses several pharmacological properties such as antinociceptive, anti-inflammatory …

Preparations from the leaves of the kratom plant (Mitragyna speciosa) are consumed for
their opioid-like effects. Several deaths have been associated with kratom used …

Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to
South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and …

Abstract Ethnopharmacological relevance Mitragyna speciosa (Korth.) or kratom is a
medicinal plant indigenous to Southeast Asia. The leaf of M. speciosa is used as a remedy …