Deep learning in cancer diagnosis, prognosis and treatment selection

KA Tran, O Kondrashova, A Bradley, ED Williams… - Genome Medicine, 2021 - Springer
Deep learning is a subdiscipline of artificial intelligence that uses a machine learning
technique called artificial neural networks to extract patterns and make predictions from …

Deep learning in histopathology: the path to the clinic

J Van der Laak, G Litjens, F Ciompi - Nature medicine, 2021 - nature.com
Abstract Machine learning techniques have great potential to improve medical diagnostics,
offering ways to improve accuracy, reproducibility and speed, and to ease workloads for …

Deep learning in cancer pathology: a new generation of clinical biomarkers

A Echle, NT Rindtorff, TJ Brinker, T Luedde… - British journal of …, 2021 - nature.com
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers.
However, the growing number of these complex biomarkers tends to increase the cost and …

Data-efficient and weakly supervised computational pathology on whole-slide images

MY Lu, DFK Williamson, TY Chen, RJ Chen… - Nature biomedical …, 2021 - nature.com
Deep-learning methods for computational pathology require either manual annotation of
gigapixel whole-slide images (WSIs) or large datasets of WSIs with slide-level labels and …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Lizard: A large-scale dataset for colonic nuclear instance segmentation and classification

S Graham, M Jahanifar, A Azam… - Proceedings of the …, 2021 - openaccess.thecvf.com
The development of deep segmentation models for computational pathology (CPath) can
help foster the investigation of interpretable morphological biomarkers. Yet, there is a major …

Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes

JA Diao, JK Wang, WF Chui, V Mountain… - Nature …, 2021 - nature.com
Computational methods have made substantial progress in improving the accuracy and
throughput of pathology workflows for diagnostic, prognostic, and genomic prediction. Still …

[HTML][HTML] Gastrointestinal cancer classification and prognostication from histology using deep learning: Systematic review

S Kuntz, E Krieghoff-Henning, JN Kather, T Jutzi… - European Journal of …, 2021 - Elsevier
Background Gastrointestinal cancers account for approximately 20% of all cancer diagnoses
and are responsible for 22.5% of cancer deaths worldwide. Artificial intelligence–based …

Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface

MV Hunter, R Moncada, JM Weiss, I Yanai… - Nature …, 2021 - nature.com
During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Cancer‐associated fibroblasts: key players in shaping the tumor immune microenvironment

M Desbois, Y Wang - Immunological reviews, 2021 - Wiley Online Library
Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer.
Nevertheless, most of the patients show innate or acquired resistance to these therapies …