Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

[HTML][HTML] Tumor extracellular vesicles drive metastasis (it's a long way from home)

S Ghoroghi, B Mary, N Asokan, JG Goetz… - FASEB …, 2021 - ncbi.nlm.nih.gov
Among a plethora of functions, extracellular vesicles released by primary tumors spread in
the organism and reach distant organs where they can induce the formation of a …

Organ-specific uptake of extracellular vesicles secreted by urological cancer cells

J Linxweiler, A Kolbinger, D Himbert, P Zeuschner… - Cancers, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) play an important role in the communication of
cancer cells with their local microenvironment and distant organ systems, in order to …

[HTML][HTML] Cytokine profiling in low-and high-density small extracellular vesicles from epidermoid carcinoma cells

JP Flemming, BL Hill, L Anderson-Pullinger… - JID Innovations, 2021 - Elsevier
Exosomes or small extracellular vesicles (sEVs) are membrane-bound nanoparticles that
carry various macromolecules and act as autocrine and paracrine signaling messengers. In …

[HTML][HTML] In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”

V Verdi, A Bécot, G van Niel, FJ Verweij - FASEB BioAdvances, 2021 - ncbi.nlm.nih.gov
To harmoniously coordinate the activities of all its different cell types, a multicellular
organism critically depends on intercellular communication. One recently discovered mode …