[HTML][HTML] Toll-like receptors in acute kidney injury

C Vázquez-Carballo, M Guerrero-Hue… - International journal of …, 2021 - mdpi.com
Acute kidney injury (AKI) is an important health problem, affecting 13.3 million
individuals/year. It is associated with increased mortality, mainly in low-and middle-income …

Toll-like receptor 4: An attractive therapeutic target for acute kidney injury

AK Jha, S Gairola, S Kundu, P Doye, AM Syed, C Ram… - Life Sciences, 2021 - Elsevier
Acute kidney injury (AKI) is a progressive renal complication which significantly affects the
patient's life with huge economic burden. Untreated acute kidney injury eventually …

[HTML][HTML] Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis

R Bhargava, S Lehoux, K Maeda, MG Tsokos… - JCI insight, 2021 - ncbi.nlm.nih.gov
Lupus nephritis (LN) is a serious complication occurring in 50% of patients with systemic
lupus erythematosus (SLE) for which there is a lack of biomarkers, a lack of specific …

[HTML][HTML] The role of the immune system in idiopathic nephrotic syndrome

A Hackl, SEDA Zed, P Diefenhardt, J Binz-Lotter… - Molecular and Cellular …, 2021 - Springer
Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and
hypoalbuminemia and usually responds well to steroids. However, relapses are frequent …

[HTML][HTML] Molecular mechanisms of proteinuria in minimal change disease

S Purohit, F Piani, FA Ordoñez… - Frontiers in …, 2021 - frontiersin.org
Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …

[HTML][HTML] Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration

J Ren, Y Xu, X Lu, L Wang, S Ide, G Hall, T Souma… - JCI insight, 2021 - ncbi.nlm.nih.gov
The transcription factor Twist1 regulates several processes that could impact kidney disease
progression, including epithelial cell differentiation and inflammatory cytokine induction …

Immunopathogenesis of idiopathic nephrotic syndrome in children: two sides of the coin

J Chen, XH Qiao, JH Mao - World Journal of Pediatrics, 2021 - Springer
Background Idiopathic nephrotic syndrome is a common form of glomerular nephropathy in
children, with an incidence rate of 1.15–16.9/100,000 depending on different nationalities …

New insights into the immunity and podocyte in glomerular health and disease: from pathogenesis to therapy in proteinuric kidney disease

PXM Rangel, A Priyadarshini… - Integrative Medicine in …, 2021 - journals.lww.com
Evidence has been furnished that immune cells, and immune-podocytes interactions have
increasingly become the focus of proteinuric kidney diseases, which affect millions of …

The long and winding road to the etiology of idiopathic nephrotic syndrome in children: Focusing on abnormalities in the gut microbiota

S Tsuji, K Kaneko - Pediatrics International, 2021 - Wiley Online Library
Childhood nephrotic syndrome is idiopathic in 90% of cases. Despite its relatively high
prevalence (30–35 per 100 000 individuals under 15 years old), the etiology of the disease …

CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent‐Relapse Minimal Change Disease

YM Teh, SK Lim, N Jusoh, K Osman… - BioMed Research …, 2021 - Wiley Online Library
Minimal change disease (MCD) is the most common cause of idiopathic nephrotic syndrome
in children, and it is well known for its multifactorial causes which are the manifestation of the …