[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
[HTML][HTML] The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind …
NV Lomakin, BA Bakirov, DN Protsenko… - Inflammation …, 2021 - Springer
Objective and design The aim of this double-blind, placebo-controlled, phase III CORONA
clinical trial was to evaluate the efficacy and safety of IL-6 receptor inhibitor levilimab (LVL) …
clinical trial was to evaluate the efficacy and safety of IL-6 receptor inhibitor levilimab (LVL) …
[HTML][HTML] Characteristics of published/registered clinical trials on COVID-19 treatment: A systematic review
P Asili, M Mirahmad, O Tabatabaei-Malazy… - DARU Journal of …, 2021 - Springer
Objectives Due to the rapid spread of COVID-19 worldwide, many countries have designed
clinical trials to find efficient treatments. We aimed to critically report the characteristics of all …
clinical trials to find efficient treatments. We aimed to critically report the characteristics of all …
[HTML][HTML] Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab …
Y Taha, H Wardle, AB Evans, ER Hunter, H Marr… - Annals of clinical …, 2021 - Springer
Background There is growing evidence that antibody responses play a role in the resolution
of SARS-CoV-2 infection. Patients with primary or secondary antibody deficiency are at …
of SARS-CoV-2 infection. Patients with primary or secondary antibody deficiency are at …
[HTML][HTML] Altered cytokine endotoxin responses in neonatal encephalopathy predict MRI outcomes
MI O'Dea, LA Kelly, E McKenna, T Strickland… - Frontiers in …, 2021 - frontiersin.org
Background: Neonatal encephalopathy (NE) is associated with adverse
neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory …
neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory …
[HTML][HTML] Tocilizumab, a humanized therapeutic IL-6 Receptor (IL-6R) monoclonal antibody, and future combination therapies for severe COVID-19
DV Parums - … Science Monitor: International Medical Journal of …, 2021 - ncbi.nlm.nih.gov
Vaccinated, non-vaccinated, and immunosuppressed individuals will continue to be infected
with SARS-CoV-2. Therefore, there is a priority to develop treatments that reduce the …
with SARS-CoV-2. Therefore, there is a priority to develop treatments that reduce the …
[HTML][HTML] Therapeutic options for Coronavirus Disease 2019 (COVID-19): where are we now?
EY Golnabi, JM Sanders, ML Johns, K Lin… - Current Infectious …, 2021 - Springer
Abstract Purpose of Review Rapidly evolving treatment paradigms of coronavirus disease
2019 (COVID-19) introduce challenges for clinicians to keep up with the pace of published …
2019 (COVID-19) introduce challenges for clinicians to keep up with the pace of published …
[HTML][HTML] Immune system disequilibrium—Neutrophils, their extracellular traps, and COVID-19-induced sepsis
C Keane, M Coalter, I Martin-Loeches - Frontiers in Medicine, 2021 - frontiersin.org
Equilibrium within the immune system can often determine the fate of its host. Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the …
[HTML][HTML] Tailored modulation of the inflammatory balance in COVID-19 patients admitted to the ICU?—a viewpoint
M Kuindersma, RR Diaz, PE Spronk - Critical Care, 2021 - Springer
A growing consensus seems to be emerging that dexamethasone is a crucial component in
the treatment of COVID-19-associated oxygen-dependent respiratory failure. Although …
the treatment of COVID-19-associated oxygen-dependent respiratory failure. Although …