Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in
water or in lipid-containing media. The predominantly lipophilic statins (simvastatin …

Abstract Purpose of Review Chronic inflammation has been recognized as one of the most
important pathophysiological mechanisms' initiation and progression of atherosclerosis …

Background Technological advances in arterial wall imaging permit the opportunity to
visualize coronary atherosclerotic plaque with sufficient resolution to characterize both its …

Objectives The authors sought to study the impact of diet and lifestyle intervention on
changes in atherosclerotic plaque volume and composition. Background Lifestyle and diet …

Atherosclerosis is a key pathological process that causes a plethora of pathologies,
including coronary artery disease, peripheral artery disease, and ischemic stroke. The silent …

Background Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been
demonstrated to produce significantly greater reduction in LDL cholesterol levels and …

Abstract Background Statins are 3‐Hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA)
reductase inhibitors blocking cholesterol biosynthesis in hepatic cells, thereby causing an …

Recent technological advances, together with an increasing body of evidence from
randomized trials, have placed coronary computer tomography angiography (CCTA) in the …

A large body of evidence arising from recent randomized clinical trials demonstrate the
association of vascular inflammatory mediators with coronary artery disease (CAD) …

There have been many meta-analyses for statins, ezetimibe and proprotein convertase
subtilisin/kexin type 9 inhibitors (PCSK9i) to evaluate clinical outcomes, but the efficacy and …