Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Factors modulating the incubation of drug and non-drug craving and their clinical implications
It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …
early abstinence and remains high during extended periods of time. Clinical evidence now …
Cocaine triggers astrocyte-mediated synaptogenesis
Background Synaptogenesis is essential in forming new neurocircuits during development,
and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of …
and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of …
Nucleus accumbens fast-spiking interneurons in motivational and addictive behaviors
The development of drug addiction is associated with functional adaptations within the
reward circuitry, within which the nucleus accumbens (NAc) is anatomically positioned as an …
reward circuitry, within which the nucleus accumbens (NAc) is anatomically positioned as an …
Effects of sex and estrous cycle on the time course of incubation of cue-induced craving following extended-access cocaine self-administration
CM Corbett, E Dunn, JA Loweth - ENeuro, 2021 - eneuro.org
Cocaine addiction is a devastating public health epidemic that continues to grow. Studies
focused on identifying biological factors influencing cocaine craving and relapse …
focused on identifying biological factors influencing cocaine craving and relapse …
Sex specific effects of “junk-food” diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core
Y Alonso-Caraballo, TL Fetterly… - …, 2021 - nature.com
CP-AMPARs in the nucleus accumbens (NAc) mediate cue-triggered motivation for food and
cocaine. In addition, increases in NAc CP-AMPAR expression and function can be induced …
cocaine. In addition, increases in NAc CP-AMPAR expression and function can be induced …
Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex
YQ Wang, J Wang, S Xia, HB Gutstein, YH Huang… - Pain, 2021 - journals.lww.com
Pain experience can change the central processing of nociceptive inputs, resulting in
persistent allodynia and hyperalgesia. However, the underlying circuit mechanisms remain …
persistent allodynia and hyperalgesia. However, the underlying circuit mechanisms remain …
GluN3-containing NMDA receptors in the rat nucleus accumbens core contribute to incubation of cocaine craving
DT Christian, MT Stefanik, LA Bean… - Journal of …, 2021 - Soc Neuroscience
Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from
cocaine self-administration in rats and humans. In rats, the expression of incubation …
cocaine self-administration in rats and humans. In rats, the expression of incubation …
mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving
Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …
[HTML][HTML] Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making
To survive in a complex environment, individuals form associations between environmental
stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral …
stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral …