A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis
Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …
Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the …
Elastic and muscular arteries differ in structure, function, and mechanical properties, and
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …
[HTML][HTML] A discrete approach for modeling degraded elastic fibers in aortic dissection
The initiation and propagation of aortic dissection have not yet been fully elucidated. An
essential role is attributed to the degradation of inter-lamellar elastic fibers in the aortic …
essential role is attributed to the degradation of inter-lamellar elastic fibers in the aortic …
[HTML][HTML] Multiscale numerical analyses of arterial tissue with embedded elements in the finite strain regime
M Dalbosco, TA Carniel, EA Fancello… - Computer Methods in …, 2021 - Elsevier
Multiscale models based on representative volume elements (RVEs) might help unraveling
the ways in which macroscopic loadings affect the microstructure of tissues reinforced by …
the ways in which macroscopic loadings affect the microstructure of tissues reinforced by …
Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall
The artery relies on interlamellar structural components, mainly elastin and collagen fibers,
for maintaining its integrity and resisting dissection propagation. In this study, the …
for maintaining its integrity and resisting dissection propagation. In this study, the …
[图书][B] Vascular Biomechanics
TC Gasser - 2021 - Springer
The development of the vascular system was a critical step in the evolution of species. It
allowed organisms to meet the growing metabolic demands and opened the door for the …
allowed organisms to meet the growing metabolic demands and opened the door for the …
Bio-composites reinforced with unique coral collagen fibers: Towards biomimetic-based small diameter vascular grafts
Abstract Cardiovascular Diseases (CVDs) are the leading cause of death worldwide.
Approximately 31% of all global deaths are caused by CVDs, of which 42% are attributable …
Approximately 31% of all global deaths are caused by CVDs, of which 42% are attributable …
Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components
S Yousef, N Matsumoto, I Dabe, M Mori, AB Landry… - Scientific Reports, 2021 - nature.com
Medial degeneration is a common histopathological finding in aortopathy and is considered
a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic …
a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic …
Differential propensity of dissection along the aorta
E Ban, C Cavinato, JD Humphrey - Biomechanics and modeling in …, 2021 - Springer
Aortic dissections progress, in part, by delamination of the wall. Previous experiments on cut-
open segments of aorta demonstrated that fluid injected within the wall delaminates the …
open segments of aorta demonstrated that fluid injected within the wall delaminates the …
The influence of sample geometry and size on porcine aortic material properties from uniaxial tensile tests using custom-designed tissue cutters, clamps and molds
M Pei, D Zou, Y Gao, J Zhang, P Huang, J Wang… - PLoS …, 2021 - journals.plos.org
The aim of this study was to identify the influence of specimen geometry and size on the
results of aortic uniaxial tensile tests using custom-designed tissue cutters, clamps and …
results of aortic uniaxial tensile tests using custom-designed tissue cutters, clamps and …