Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues

MH Sheikh, M Errede, A d'Amati, NQ Khan, S Fanti… - Faseb Journal, 2021 - ora.ox.ac.uk
Mounting evidence has linked the metabolic disease to neurovascular disorders and
cognitive decline. Using a murine model of a high-fat high-sugar diet mimicking obesity …

[HTML][HTML] The role of PDE8 in T cell recruitment and function in inflammation

PM Epstein, C Basole, S Brocke - Frontiers in Cell and …, 2021 - frontiersin.org
Inhibitors targeting cyclic nucleotide phosphodiesterases (PDEs) expressed in leukocytes
have entered clinical practice to treat inflammatory disorders, with three PDE4 inhibitors …

Neutrophil-derived myeloperoxidase facilitates both the induction and elicitation phases of contact hypersensitivity

A Strzepa, CJ Gurski, LJ Dittel, M Szczepanik… - Frontiers in …, 2021 - frontiersin.org
Background Allergic contact dermatitis (ACD) is a common skin disorder affecting an
estimated 15-20% of the general population. The mouse model of ACD is contact …

A novel rat model of chronic subdural hematoma: Induction of inflammation and angiogenesis in the subdural space mimicking human-like features of progressively …

X Xu, D Wang, Z Han, B Wang, W Gao, Y Fan, F Li… - Brain Research …, 2021 - Elsevier
Pathophysiological mechanisms of chronic subdural hematoma (CSDH) involve localized
inflammation, angiogenesis, and dysregulated coagulation and fibrinolysis. The scarcity of …

Impact of metabolic disorders on the structure, function, and immunological integrity of the blood-brain barrier.

MH Sheikh - 2021 - qmro.qmul.ac.uk
Metabolic disorders induce a low-grade chronic inflammatory state that is damaging to the
peripheral vasculature, leading to cardiovascular diseases. In recent years, there has been …

[PDF][PDF] Author's Declaration

R Kaur - 2021 - rshare.library.torontomu.ca
USE OF PULSED HIGH INTENSITY FOCUSED ULTRASOUND TO STUDY THE RESPONSE
OF BRAIN ENDOTHELIAL CELLS TO MECHANICAL INJURY By Rajwin Page 1 USE OF …

[PDF][PDF] In vitro investigation of polydopamine-nanoparticles to overcome an intact blood-brain barrier

VK Augstein - 2021 - pure.mpg.de
One of the most challenging hurdles in treating the central nervous system (CNS) is to
overcome the blood-brain barrier (BBB). Caused by the BBB, currently therapies for …