The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation
BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …
metabolism, glucose tolerance, immune system maturation and function in humans …
[HTML][HTML] The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity
S Chen, X Liu, C Peng, C Tan, H Sun, H Liu, Y Zhang… - Cell Metabolism, 2021 - cell.com
Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …
treatment of obesity. However, pharmacologic engagement of this process has proven …
[HTML][HTML] The interplay of glucagon-like peptide-1 receptor trafficking and signalling in pancreatic beta cells
A Marzook, A Tomas, B Jones - Frontiers in endocrinology, 2021 - frontiersin.org
The glucagon-like peptide 1 receptor (GLP-1R) is a class BG protein-coupled receptor
(GPCR) which mediates the effects of GLP-1, an incretin hormone secreted primarily from L …
(GPCR) which mediates the effects of GLP-1, an incretin hormone secreted primarily from L …
Metabolic determinants of Alzheimer's disease: A focus on thermoregulation
M Tournissac, M Leclerc, J Valentin-Escalera… - Ageing Research …, 2021 - Elsevier
Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …
[HTML][HTML] Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
F Zhang, Z Chen, D Wu, L Tian, Q Chen, Y Ye, W Chen… - Iscience, 2021 - cell.com
GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but
its role in adipose tissues remains to be elucidated. The aim of this study was to determine …
its role in adipose tissues remains to be elucidated. The aim of this study was to determine …
[HTML][HTML] Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised …
A Veelen, E Erazo-Tapia, J Oscarsson… - Molecular Metabolism, 2021 - Elsevier
Background Type 2 diabetes is a syndrome defined by hyperglycaemia that is the result of
various degrees of pancreatic β-cell failure and reduced insulin sensitivity. Despite the fact …
various degrees of pancreatic β-cell failure and reduced insulin sensitivity. Despite the fact …
Exercise and adipose tissue immunity: outrunning inflammation
Chronic inflammation is considered a precipitating factor and possibly an underlying cause
of many noncommunicable diseases, including cardiovascular disease, metabolic diseases …
of many noncommunicable diseases, including cardiovascular disease, metabolic diseases …
Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications
LY Cheong, A Xu - Journal of molecular cell biology, 2021 - academic.oup.com
Adipose tissue (AT) is highly plastic and heterogeneous in response to environmental and
nutritional changes. The development of heat-dissipating beige adipocytes in white AT …
nutritional changes. The development of heat-dissipating beige adipocytes in white AT …