Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …

The glucagon-like peptide 1 receptor (GLP-1R) is a class BG protein-coupled receptor
(GPCR) which mediates the effects of GLP-1, an incretin hormone secreted primarily from L …

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …

GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but
its role in adipose tissues remains to be elucidated. The aim of this study was to determine …

Background Type 2 diabetes is a syndrome defined by hyperglycaemia that is the result of
various degrees of pancreatic β-cell failure and reduced insulin sensitivity. Despite the fact …

Chronic inflammation is considered a precipitating factor and possibly an underlying cause
of many noncommunicable diseases, including cardiovascular disease, metabolic diseases …

Adipose tissue (AT) is highly plastic and heterogeneous in response to environmental and
nutritional changes. The development of heat-dissipating beige adipocytes in white AT …