Accurate pathogenicity prediction of missense variants is critically important in genetic
studies and clinical diagnosis. Previously published prediction methods have facilitated the …

As a newly discovered protein posttranslational modification, histone lysine crotonylation
(Kcr) involved in cellular regulation and human diseases. Various proteomics technologies …

Abstract Analysis of molecular pathway activation is the recent instrument that helps to
quantize activities of various intracellular signaling, structural, DNA synthesis and repair …

Precise multiplexed quantification of proteins in biological samples can be achieved by
targeted proteomics using multiple or parallel reaction monitoring (MRM/PRM). Combined …

Rationale & Objective Pathogenic variants in type IV collagen have been reported to
account for a significant proportion of chronic kidney disease. Accordingly, genetic testing is …

Transcriptional regulation is associated with complicated mechanisms including multiple
molecular interactions and collaborative drive. Long noncoding RNAs (lncRNAs) have …

Recent innovation in the field of machine learning has been enabled by the confluence of
three advances: rapid expansion of affordable computing power in the form of cloud …

In the last decade, genome-scale metabolic models have been increasingly used to study
plant metabolic behaviour at the tissue and multi-tissue level in different environmental …

The Anopheles gambiae's CYP6Z3 protein belongs to the Cytochrome P450 family and
functions in oxidation-reduction processes, many studies including our previous work on …

Discriminating between deleterious and neutral mutations among numerous non-
synonymous single nucleotide variants (nsSNVs) that may be observed through whole …