[HTML][HTML] Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
[HTML][HTML] Thiazole, triazole, thio-and semicarbazone derivatives-Promising moieties for drug development for the treatment of tuberculosis
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …
Copper(II) N,N,O-Chelating Complexes as Potential Anticancer Agents
Three novel dinuclear Cu (II) complexes based on a N, N, O-chelating salphen-like ligand
scaffold and bearing varying aromatic substituents (− H,− Cl, and− Br) have been …
scaffold and bearing varying aromatic substituents (− H,− Cl, and− Br) have been …
N-substitution in isatin thiosemicarbazones decides nuclearity of Cu (II) complexes–Spectroscopic, molecular docking and cytotoxic studies
Abstract The mono-(1) and bi-nuclear (2) copper (II) complexes containing N-substituted
isatin thiosemicarbazone (s) were synthesized, and characterized by analytical and …
isatin thiosemicarbazone (s) were synthesized, and characterized by analytical and …
Chemodynamic therapy agents Cu (II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells
WY Shen, CP Jia, AN Mo, H Liang, ZF Chen - European Journal of …, 2021 - Elsevier
Three Cu (II) complexes of quinoline derivatives as cancer chemodynamic therapy agents
were synthesized and characterized. These complexes were heavily taken up by cells and …
were synthesized and characterized. These complexes were heavily taken up by cells and …
Copper (II) complexes based on thiosemicarbazone ligand: Preparation, crystal structure, Hirshfeld surface, energy framework, antiMycobacterium activity, in silico …
RAC Souza, WRP Costa, EF Faria, MAS Bessa… - Journal of Inorganic …, 2021 - Elsevier
Considering the promising previous results on the remarkable activity exhibited by cobalt (III)
and manganese (II) thiosemicarbazone compounds as antibacterial agents, the present …
and manganese (II) thiosemicarbazone compounds as antibacterial agents, the present …
Triapine analogues and their copper (II) complexes: Synthesis, characterization, solution speciation, redox activity, cytotoxicity, and mR2 RNR inhibition
I Besleaga, I Stepanenko, TV Petrasheuskaya… - Inorganic …, 2021 - ACS Publications
Three new thiosemicarbazones (TSCs) HL 1–HL 3 as triapine analogues bearing a redox-
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
Oxovanadium (IV) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, anticancer enzyme inhibition and in vitro cytotoxicity on breast cancer …
Five oxovanadium (IV) complexes were synthesized using acetyl-and benzoylacetone-S-
alkyl-thiosemicarbazones (alkyl= methyl, ethyl, propyl or butyl) and salicylaldehyde …
alkyl-thiosemicarbazones (alkyl= methyl, ethyl, propyl or butyl) and salicylaldehyde …
Structure elucidation, in vitro binding studies and ROS-dependent anti-cancer activity of Cu(II) and Zn(II) phthaloylglycinate(phen) complexes against MDA-MB-231 …
S Zehra, I Cirilli, S Silvestri, S Gómez-Ruiz… - Metallomics, 2021 - academic.oup.com
New mononuclear Cu (II) and Zn (II)-based complexes 1 [Cu (L) 2 (diimine) HOCH3] and 2
[Zn (L) 2 (diimine)] have been synthesized as anti-cancer chemotherapeutics targeted to …
[Zn (L) 2 (diimine)] have been synthesized as anti-cancer chemotherapeutics targeted to …
[HTML][HTML] Coumarin-Based Triapine Derivatives and Their Copper (II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity
I Stepanenko, MV Babak, G Spengler, M Hammerstad… - Biomolecules, 2021 - mdpi.com
A series of thiosemicarbazone-coumarin hybrids (HL1-HL3 and H2L4) has been
synthesised in 12 steps and used for the preparation of mono-and dinuclear copper (II) …
synthesised in 12 steps and used for the preparation of mono-and dinuclear copper (II) …