TGF-β signaling and resistance to cancer therapy

M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

L Liu, T Tao, S Liu, X Yang, X Chen, J Liang… - Nature …, 2021 - nature.com
Notch signaling represents a key mechanism mediating cancer metastasis and stemness.
To understand how Notch signaling is overactivated to couple tumor metastasis and self …

Exosomal miR-128-3p promotes epithelial-to-mesenchymal transition in colorectal cancer cells by targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 signaling

J Bai, X Zhang, D Shi, Z Xiang, S Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a key process that occurs during tumor
metastasis, affecting a variety of malignancies including colorectal cancer (CRC). Exosomes …

MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer

S Tang, S Li, T Liu, Y He, H Hu, Y Zhu, S Tang, H Zhou - Cancer Letters, 2021 - Elsevier
Lung cancer is one of the most common solid tumors worldwide and the leading cause of
cancer-related deaths, causing a devastating impact on human health. The clinical …

[HTML][HTML] miR-340: A multifunctional role in human malignant diseases

Z Huang, Y Xu, M Wan, X Zeng, J Wu - International Journal of …, 2021 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a class of short non-coding RNAs of approximately 22 nucleotides
in length, which function by binding to the 3'UTR sequences of their target mRNAs. It has …

TRIM11 promotes proliferation, migration, invasion and EMT of gastric cancer by activating β-catenin signaling

Q Lan, X Tan, P He, W Li, S Tian… - OncoTargets and …, 2021 - Taylor & Francis
Introduction Gastric cancer (GC) is the sixth most common malignant tumor and the third
leading cause of cancer-related death in the world. Studies have shown that TRIM protein …

Cell behavior of non-small cell lung cancer is at EGFR and microRNAs hands

SS Hassanein, SA Ibrahim… - International journal of …, 2021 - mdpi.com
Lung cancer is a complex disease associated with gene mutations, particularly mutations of
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and epidermal growth factor receptor …

[HTML][HTML] Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis

B Wang, X Sun, KJ Huang, LS Zhou… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through
miRNA-128-3p/GOLM1 axis - PMC Back to Top Skip to main content NIH NLM Logo Access …

LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells

Q Geng, Z Li, X Li, Y Wu, N Chen - Journal of Bioenergetics and …, 2021 - Springer
Lung cancer is one of the most common malignant tumors in the world. Non-small cell lung
cancer (NSCLC) accounts for about 80% of all lung cancers. About 75% of patients are in …