Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …

Substance use disorders (SUDs) are ubiquitous throughout the world. However, much
remains to be done to develop pharmacotherapies that are very efficacious because the …

N‐acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine‐and cue‐primed
reinstatement of cocaine‐seeking behavior in preclinical studies. In this inpatient study, the …

Drug compulsion manifests in some but not all individuals and implicates multifaceted
processes including failures in top‐down cognitive control as drivers for the hazardous …

Introduction: Major depressive disorder (MDD) and cocaine use disorder (CUD) are
prevalent and frequently co-occur. When co-occurring, the presence of one disorder typically …

Objective Pharmacological manipulations of glutamatergic ionotropic receptors have been
suggested as a promising target for addiction treatment. Antagonists of AMPA/kainate …

Morphine is one of the most abused drugs in the world, which has resulted in serious social
problems. The frontal association cortex (FrA) has been shown to play a key role in memory …

Rationale Methamphetamine (METH) induces changes in the glutamatergic system and
elicits cellular alterations in the cortico-accumbens circuit. Objective While there is a body of …

Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of
relapse. Currently there are no approved effective pharmacotherapies for METH …

One of the best-established findings in behavioural neuroscience is that mesocorticolimbic
dopamine (DA) transmission influences reward-related processes. Despite this consensus …