Use of fractional exhaled nitric oxide to guide the treatment of asthma: an official American Thoracic Society clinical practice guideline

SB Khatri, JM Iaccarino, A Barochia… - American journal of …, 2021 - atsjournals.org
Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …

The Saudi Initiative for Asthma-2021 Update: Guidelines for the diagnosis and management of asthma in adults and children

MS Al-Moamary, SA Alhaider, AA Alangari… - Annals of thoracic …, 2021 - journals.lww.com
Abstract The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma
guidelines for the diagnosis and management of asthma for adults and children, which is …

An update on the epigenetics of asthma

O Gruzieva, SK Merid, GH Koppelman… - Current opinion in …, 2021 - journals.lww.com
Further research is needed to explore the diagnostic and therapeutic potential of epigenetic
modifications in asthma. Multiomics studies on asthma will become increasingly important …

Drug repurposing to treat glucocorticoid resistance in asthma

AL Wang, R Panganiban, W Qiu, AT Kho… - Journal of Personalized …, 2021 - mdpi.com
Corticosteroid resistance causes significant morbidity in asthma, and drug repurposing may
identify timely and cost-effective adjunctive treatments for corticosteroid resistance. In 95 …

Direct and indirect bronchoprovocation tests in dose‐response studies of inhaled corticosteroids: Past, present, and future directions

CM Blais, BE Davis, P Nair, DW Cockcroft - Allergy, 2021 - Wiley Online Library
Inhaled corticosteroids (ICS) are a mainstay of treatment in eosinophilic asthma. Many
studies have explored the dose‐response effect of different formulations of ICS through …

[HTML][HTML] Plasma levels of BAFF and APRIL are elevated in patients with asthma in Saudi Arabia

W Alturaiki, A Mubarak, SA Mir, A Afridi… - Saudi Journal of …, 2021 - Elsevier
B-cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of
the tumor necrosis factor superfamily of cytokines and can induce B cell activation …

Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma

N Hernandez-Pacheco, M Gorenjak, J Li… - Journal of personalized …, 2021 - mdpi.com
Inhaled corticosteroids (ICS) are the most common asthma controller medication. An
important contribution of genetic factors in ICS response has been evidenced. Here, we …

High fractional exhaled nitric oxide levels in asthma patients: Does size matter?

N Diamant, I Amirav, K Armoni‐Domany… - Pediatric …, 2021 - Wiley Online Library
Background Fractional exhaled nitric oxide (FeNO) is a biomarker for eosinophilic
inflammation used for diagnosis and monitoring of asthma. High FeNO indicates significant …

A low exhaled nitric oxide level excludes a short‐term benefit from inhaled corticosteroids in suspected asthma: A randomized placebo‐controlled trial

L Sutherland, K Shaw, C Parrish, N Singleton… - …, 2021 - Wiley Online Library
Background and objective Fractional exhaled nitric oxide (FeNO) is a non‐invasive
biomarker that reflects IL‐4/IL‐13 production and therefore represents T2 allergic …

[HTML][HTML] Eosinophils and childhood asthma

BS Choi - Clinical and Experimental Pediatrics, 2021 - ncbi.nlm.nih.gov
Eosinophils are a type of granulocyte with eosinophilic granules in the cytoplasm that play
an important role in allergic and parasitic diseases. Eosinophils are important in the …