Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

Phosphorylation is a form of protein posttranslational modification (PTM) that regulates many
biological processes. Whereas phosphoproteomics is a scientific discipline that identifies …

Mass spectrometry (MS)-based phosphoproteomics has revolutionized our ability to profile
phosphorylation-based signaling in cells and tissues on a global scale. To infer the action of …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin …

Nitric oxide (NO), a free radical, plays a critical role in a wide range of physiological and
pathological processes. Due to its pleiotropic function, it has been widely investigated in …

Deep representations can be used to replace human-engineered representations, as such
features are constrained by certain limitations. For the prediction of protein post-translation …

As an important post-translational modification (PTM), protein phosphorylation is involved in
the regulation of almost all of biological processes in eukaryotes. Due to the rapid progress …

Introduction Many pathologies, including cancer, have been associated with aberrant
phosphorylation-mediated signaling networks that drive altered cell proliferation, migration …

Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and
degradation, and can be targeted for disease treatment when the abnormal expression of …