[HTML][HTML] European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in …

J van Prehn, E Reigadas, EH Vogelzang… - Clinical Microbiology …, 2021 - Elsevier
Abstract Scope In 2009, the European Society of Clinical Microbiology and Infectious
Diseases (ESCMID) published the first treatment guidance document for Clostridioides …

Economic burden and cost-effectiveness of therapies for Clostridiodes difficile infection: a narrative review

A Gupta, AN Ananthakrishnan - Therapeutic Advances in …, 2021 - journals.sagepub.com
Clostridioides difficile is the most common cause of healthcare-associated diarrhea. Disease
complications as well as recurrent infections contribute significantly to morbidity and …

[HTML][HTML] The case against antibiotics and for anti-virulence therapeutics

JA Hotinger, ST Morris, AE May - Microorganisms, 2021 - mdpi.com
Although antibiotics have been indispensable in the advancement of modern medicine,
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …

Clinical complications in patients with primary and recurrent Clostridioides difficile infection: A real-world data analysis

P Feuerstadt, M Boules, L Stong… - SAGE open …, 2021 - journals.sagepub.com
Objective: Clostridioides difficile infection and recurrent C. difficile infection result in
substantial economic burden and healthcare resource use. Sepsis and bowel surgery are …

[HTML][HTML] Rapid ultra-sensitive diagnosis of clostridium difficile infection using a SERS-based lateral flow assay

WA Hassanain, J Spoors, CL Johnson, K Faulds… - Analyst, 2021 - pubs.rsc.org
Clostridium difficile (C. diff) infection is one of the most contagious diseases associated with
high morbidity and mortality rates in hospitalised patients. Accurate diagnosis can slow its …

[HTML][HTML] Clostridioides difficile Infection, Still a Long Way to Go

E Kampouri, A Croxatto, G Prod'hom… - Journal of Clinical …, 2021 - mdpi.com
Clostridioides difficile is an increasingly common pathogen both within and outside the
hospital and is responsible for a large clinical spectrum from asymptomatic carriage to …

[HTML][HTML] Production of p-cresol by Decarboxylation of p-HPA by All Five Lineages of Clostridioides difficile Provides a Growth Advantage

MA Harrison, H Kaur, BW Wren… - Frontiers in Cellular and …, 2021 - frontiersin.org
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and is capable
of causing severe symptoms, such as pseudomembranous colitis and toxic megacolon. An …

Antibiotic exposure and the risk of hospital-acquired diarrhoea and Clostridioides difficile infection: a cohort study

V Schechner, N Fallach, T Braun… - Journal of …, 2021 - academic.oup.com
Background Hospital-acquired diarrhoea (HAD) and Clostridioides difficile infection (CDI)
may be triggered by antibiotic use. Objectives To determine the effect of specific antibiotic …

A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two …

A Miles-Jay, VB Young, EG Pamer… - Microbial …, 2021 - microbiologyresearch.org
Clostridioides difficile is the leading cause of healthcare-associated infectious diarrhoea.
However, it is increasingly appreciated that healthcare-associated infections derive from …

Clostridioides difficile: innovations in target discovery and potential for therapeutic success

TM Monaghan, AM Seekatz, BH Mullish… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Clostridioides difficile infection (CDI) remains a worldwide clinical problem.
Increased incidence of primary infection, occurrence of hypertoxigenic ribotypes, and more …