Neuroinflammation in HIV-related neuropathic pain
HJ Lu, YY Fu, QQ Wei, ZJ Zhang - Frontiers in Pharmacology, 2021 - frontiersin.org
In the management of human immunodeficiency virus (HIV) infection around the world,
chronic complications are becoming a new problem along with the prolonged life …
chronic complications are becoming a new problem along with the prolonged life …
HMGB1 released from nociceptors mediates inflammation
Inflammation, the body's primary defensive response system to injury and infection, is
triggered by molecular signatures of microbes and tissue injury. These molecules also …
triggered by molecular signatures of microbes and tissue injury. These molecules also …
Reactive oxygen species (ROS) are critical for morphine exacerbation of HIV-1 gp120-induced pain
Many HIV patients develop chronic pain and use opioid-derived medicine as primary
analgesics. Emerging clinical evidence suggests that chronic use of opioid analgesics …
analgesics. Emerging clinical evidence suggests that chronic use of opioid analgesics …
Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain
AJ Kwilasz, SMG Fulgham, JC Duran-Malle… - Brain, behavior, and …, 2021 - Elsevier
Neuropathic pain is a major symptom of multiple sclerosis (MS) with up to 92% of patients
reporting bodily pain, and 85% reporting pain severe enough to cause functional disability …
reporting bodily pain, and 85% reporting pain severe enough to cause functional disability …
A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain
More than a quarter of veterans of the 1990–1991 Persian Gulf War suffer from Gulf War
Illness (GWI), a chronic, multi-symptom illness that commonly includes musculoskeletal pain …
Illness (GWI), a chronic, multi-symptom illness that commonly includes musculoskeletal pain …
HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status
Hypogonadism is a common comorbidity associated with HIV-1 that is more prevalent
among infected individuals over the age of 45. The underlying mechanisms are unknown …
among infected individuals over the age of 45. The underlying mechanisms are unknown …
Large mitochondrial DNA deletions in HIV sensory neuropathy
RH Roda, D Bargiela, W Chen, K Perry, RJ Ellis… - Neurology, 2021 - AAN Enterprises
Objective The primary objective of this study was to evaluate the correlation of large
mitochondrial DNA (mtDNA) deletions in skin samples of people with HIV (PWH) with …
mitochondrial DNA (mtDNA) deletions in skin samples of people with HIV (PWH) with …
Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and …
TJ Cirino, AR Alleyne, V Duarte, A Figueroa… - Journal of Neuroimmune …, 2021 - Springer
Despite the success of combined antiretroviral therapy (cART) in reducing viral load, a
substantial portion of Human Immunodeficiency Virus (HIV)+ patients report chronic pain …
substantial portion of Human Immunodeficiency Virus (HIV)+ patients report chronic pain …
[HTML][HTML] HIV-related Neuropathy: pathophysiology, treatment and challenges
N Jazebi, C Evans, HS Kadaru… - Journal of neurology …, 2021 - ncbi.nlm.nih.gov
Abstract HIV-sensory neuropathy (HIV-SN) is a debilitating complication in HIV patients with
or without anti-retroviral treatment (ART). Common symptoms of HIV-SN include pain …
or without anti-retroviral treatment (ART). Common symptoms of HIV-SN include pain …
[HTML][HTML] Green light antinociceptive and reversal of thermal and mechanical hypersensitivity effects rely on endogenous opioid system stimulation
Benefits of phototherapy were characterized in multiple diseases including depression,
circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia …
circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia …