Mucociliary respiratory epithelium integrity in molecular defense and susceptibility to pulmonary viral infections
Adivitiya, MS Kaushik, S Chakraborty, S Veleri… - Biology, 2021 - mdpi.com
Simple Summary Mucociliary clearance constitutes an innate lung defense mechanism that
is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways …
is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways …
Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia
Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …
transmembrane conductance regulator) is required for precision medicine therapies for CF …
Proteases, mucus, and mucosal immunity in chronic lung disease
Dysregulated protease activity has long been implicated in the pathogenesis of chronic lung
diseases and especially in conditions that display mucus obstruction, such as chronic …
diseases and especially in conditions that display mucus obstruction, such as chronic …
SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport
R Abdel Hameid, E Cormet-Boyaka… - … of Physiology-Lung …, 2021 - journals.physiology.org
The tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus
responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, toward the …
responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, toward the …
Chronic rhinosinusitis with nasal polyps is associated with impaired TMEM16A-mediated epithelial chloride secretion
JJ Salomon, T Albrecht, SY Graeber… - Journal of Allergy and …, 2021 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most common
chronic disorders with limited therapeutic options. However, the pathogenesis of CRSwNP …
chronic disorders with limited therapeutic options. However, the pathogenesis of CRSwNP …
Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is frequently
found in the airways of cystic fibrosis (CF) patients due to the dehydrated mucus that …
found in the airways of cystic fibrosis (CF) patients due to the dehydrated mucus that …
Airway epithelial nucleotide release contributes to mucociliary clearance
C van Heusden, BR Grubb, B Button, ER Lazarowski - Life, 2021 - mdpi.com
Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In
health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant …
health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant …
Purinergic receptors in airway hydration
ER Lazarowski, RC Boucher - Biochemical pharmacology, 2021 - Elsevier
Airway epithelial purinergic receptors control key components of the mucociliary clearance
(MCC), the dominant component of pulmonary host defense. In healthy airways, the …
(MCC), the dominant component of pulmonary host defense. In healthy airways, the …
Variability in tracheal mucociliary transport is not controlled by beating cilia in lambs in vivo during ventilation with humidified and nonhumidified air
Mucociliary transport in the respiratory epithelium depends on beating of cilia to move a
mucus layer containing trapped inhaled particles toward the mouth. Little is known about the …
mucus layer containing trapped inhaled particles toward the mouth. Little is known about the …
cAMP triggers Na+ absorption by distal airway surface epithelium in cystic fibrosis swine
A controversial hypothesis pertaining to cystic fibrosis (CF) lung disease is that the CF
transmembrane conductance regulator (CFTR) channel fails to inhibit the epithelial Na+ …
transmembrane conductance regulator (CFTR) channel fails to inhibit the epithelial Na+ …