The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …

Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models,
whether and how grafts functionally repair damaged neural circuitry in the adult brain is not …

Pathophysiological damages and loss of function of dopamine neurons precede their
demise and contribute to the early phases of Parkinson's disease. The presence of aberrant …

Progressive neuronal loss is a hallmark of many neurodegenerative diseases, including
Alzheimer's and Parkinson's disease. These pathologies exhibit clear signs of inflammation …

Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA
levels. During the interspike intervals, subthreshold slow depolarization underlies …

Parkinson's disease (PD) is a chronic neurodegenerative disorder associated with
dopamine neuron loss and motor dysfunction. Neuroprotective agents that prevent …

The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN)
underlies the core motor symptoms of the progressive movement disorder Parkinson's …

Pathophysiological changes in dopamine neurons precede their demise and contribute to
the early phases of Parkinson's disease (PD). Intracellular pathological inclusions of the …

Parkinson's disease (PD) is the second most prominent neurodegenerative disease around
the world. Although it is known that PD is caused by the loss of dopaminergic cells in …