[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Management of Obesity in Cardiovascular Practice: JACC Focus Seminar

JP Despres, AC Carpentier, A Tchernof… - Journal of the American …, 2021 - jacc.org
Obesity contributes to reduced life expectancy because of its link with type 2 diabetes and
cardiovascular disease. Yet, targeting this poorly diagnosed, ill-defined, and …

Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease

A Fuchs, D Samovski, GI Smith, V Cifarelli, SS Farabi… - Gastroenterology, 2021 - Elsevier
Background And Aims Insulin resistance is a key factor in the pathogenesis of nonalcoholic
fatty liver disease (NAFLD). We evaluated the importance of subcutaneous abdominal …

[HTML][HTML] Adipocyte, immune cells, and miRNA crosstalk: a novel regulator of metabolic dysfunction and obesity

S Kiran, V Kumar, S Kumar, RL Price, UP Singh - Cells, 2021 - mdpi.com
Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue
(AT) accompanied with alterations in the immune response that affects virtually all age and …

[HTML][HTML] On the role of paraoxonase-1 and chemokine ligand 2 (CC motif) in metabolic alterations linked to inflammation and disease. A 2021 update

J Camps, H Castañé, E Rodríguez-Tomàs… - Biomolecules, 2021 - mdpi.com
Infectious and many non-infectious diseases share common molecular mechanisms. Among
them, oxidative stress and the subsequent inflammatory reaction are of particular note …

Sphingosine 1-phosphate metabolism and insulin signaling

D Wigger, F Schumacher, S Schneider-Schaulies… - Cellular …, 2021 - Elsevier
Insulin is the main anabolic hormone secreted by β-cells of the pancreas stimulating the
assimilation and storage of glucose in muscle and fat cells. It modulates the postprandial …

[HTML][HTML] Adipose tissue steroid receptor rna activator 1 (sra1) expression is associated with obesity, insulin resistance, and inflammation

S Kochumon, H Arefanian, S Sindhu, S Shenouda… - Cells, 2021 - mdpi.com
Steroid receptor RNA activator 1 (SRA1) is involved in pathophysiological responses of
adipose tissue (AT) in obesity. In vitro and animal studies have elucidated its role in meta …

[HTML][HTML] Effects of intermittent hypoxia on cytokine expression involved in insulin resistance

T Uchiyama, H Ota, C Ohbayashi… - International Journal of …, 2021 - mdpi.com
Sleep apnea syndrome (SAS) is a prevalent disorder characterized by recurrent apnea or
hypoxia episodes leading to intermittent hypoxia (IH) and arousals during sleep. Currently …

[HTML][HTML] Insulin/IGF-1 signaling is downregulated in Barrett's esophagus patients undergoing a moderate calorie and protein restriction program: a randomized 2-year …

D Arcidiacono, A Zaramella, F Fabris… - Nutrients, 2021 - mdpi.com
Obesity and associated insulin resistance (Ins-R) have been identified as important risk
factors for esophageal adenocarcinoma development. Elevated calories and protein …

[HTML][HTML] Metformin and vitamin d modulate inflammation and autophagy during adipose-derived stem cell differentiation

S Cruciani, G Garroni, R Pala, ML Cossu… - International Journal of …, 2021 - mdpi.com
Adipose-derived stem cells (ADSCs) came out from the regenerative medicine landscape for
their ability to differentiate into several phenotypes, contributing to tissue regeneration both …