Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging
Background Detecting subtle-to-moderate biomarker changes such as those in amyloid PET
imaging becomes increasingly relevant in the context of primary and secondary prevention …
imaging becomes increasingly relevant in the context of primary and secondary prevention …
The synaptic vesicle protein 2A interacts with key pathogenic factors in Alzheimer's disease: implications for treatment
Y Kong, L Huang, W Li, X Liu, Y Zhou, C Liu… - Frontiers in cell and …, 2021 - frontiersin.org
Alzheimer's disease (AD), a serious neurodegenerative disease, is pathologically
characterized by synaptic loss and dysfunction. Synaptic vesicle protein 2A (SV2A) is an …
characterized by synaptic loss and dysfunction. Synaptic vesicle protein 2A (SV2A) is an …
Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies
H Tuncel, D Visser, M Yaqub, T Timmers… - Molecular Imaging and …, 2021 - Springer
Purpose Dynamic positron emission tomography (PET) protocols allow for accurate
quantification of [18 F] flortaucipir-specific binding. However, dynamic acquisitions can be …
quantification of [18 F] flortaucipir-specific binding. However, dynamic acquisitions can be …
[HTML][HTML] Dual-phase 18F-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease
Background This study investigated changes in brain perfusion and Aβ burden according to
the progression of Alzheimer's disease (AD) by using a dual-phase 18 F-florbetaben (FBB) …
the progression of Alzheimer's disease (AD) by using a dual-phase 18 F-florbetaben (FBB) …
Simulating the effect of cerebral blood flow changes on regional quantification of [18F]flutemetamol and [18F]florbetaben studies
F Heeman, M Yaqub, I Lopes Alves… - Journal of Cerebral …, 2021 - journals.sagepub.com
Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative
estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed …
estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed …
High Correlation of Static First-Minute-Frame (FMF) PET Imaging after 18F-Labeled Amyloid Tracer Injection with [18F]FDG PET Imaging
AP Seiffert, A Gómez-Grande, A Villarejo-Galende… - Sensors, 2021 - mdpi.com
Dynamic early-phase PET images acquired with radiotracers binding to fibrillar amyloid-beta
(Aβ) have shown to correlate with [18F] fluorodeoxyglucose (FDG) PET images and provide …
(Aβ) have shown to correlate with [18F] fluorodeoxyglucose (FDG) PET images and provide …
Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
Little is known about whether early-phase PET images of 18F-FP-CIT match those of
amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET …
amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET …
[PDF][PDF] Alzheimer's disease diagnosis based on a semantic rule-based modeling and reasoning approach
N Shoaip, A Rezk, S EL-Sappagh… - Comput. Mater …, 2021 - researchgate.net
Alzheimer's disease (AD) is a very complex disease that causes brain failure, then
eventually, dementia ensues. It is a global health problem. 99% of clinical trials have failed …
eventually, dementia ensues. It is a global health problem. 99% of clinical trials have failed …
Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB
F Heeman, J Hendriks, I Lopes Alves… - Molecular Imaging and …, 2021 - Springer
Purpose Moderate-to-high correlations have been reported between the [11 C] PiB PET-
derived relative tracer delivery rate R 1 and relative CBF as measured using [15 O] H 2 O …
derived relative tracer delivery rate R 1 and relative CBF as measured using [15 O] H 2 O …
Comparison of early F-18 Florbetaben PET/CT to Tc-99m ECD SPECT using voxel, regional, and network analysis
This study aimed to validate early-phase F-18 Florbetaben positron emission tomography
(eFBB PET) as a brain perfusion test and determine the optimal reference region. A total of …
(eFBB PET) as a brain perfusion test and determine the optimal reference region. A total of …