[HTML][HTML] Iron homeostasis disorder and Alzheimer's disease

Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

[HTML][HTML] MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

N Chopra, R Wang, B Maloney, K Nho, JS Beck… - Molecular …, 2021 - nature.com
Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …

[HTML][HTML] LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro-27a-3p

LX Dong, YY Zhang, HL Bao, Y Liu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Objective: Alzheimer's disease (AD) is a common neurodegenerative disease. This study
was designed to investigate the roles of lncRNA NEAT1/miR-27a-3p axis in AD. Methods …

[HTML][HTML] RNA dynamics in Alzheimer's disease

A Rybak-Wolf, M Plass - Molecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …

[HTML][HTML] MicroRNAs as potential orchestrators of Alzheimer's disease-related pathologies: insights on current status and future possibilities

NZ Abuelezz, FE Nasr, MA AbdulKader… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

[HTML][HTML] The role of non-coding RNAs in Alzheimer's disease: from regulated mechanism to therapeutic targets and diagnostic biomarkers

Y Zhang, Y Zhao, X Ao, W Yu, L Zhang… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD is characterized
by the production and aggregation of beta-amyloid (Aβ) peptides, hyperphosphorylated tau …

Non-coding RNAs: Emerging from the discovery to therapeutic applications

B Baptista, M Riscado, JA Queiroz, C Pichon… - Biochemical …, 2021 - Elsevier
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …

[HTML][HTML] MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease

S Kumar, H Morton, N Sawant, E Orlov, LE Bunquin… - Redox biology, 2021 - Elsevier
Abstract Background MicroRNA-455-3p is one of the highly conserved miRNAs involved in
multiple cellular functions in humans and we explored its relevance to learning and memory …

CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid β-induced neuronal injury in Alzheimer's Disease

L Wu, Q Du, C Wu - Brain Research, 2021 - Elsevier
Abstract Background Alzheimer's Disease (AD) is a neurodegenerative disorder
characterized by progressive memory loss and cognition and language impairment …