[HTML][HTML] The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
[HTML][HTML] Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …
was identified as an important player in a complex neurodegenerative disease that affects> …
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
[HTML][HTML] Neuropharmacological effects of quercetin: a literature-based review
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …
beneficial properties in many pathologies. Its neuroprotective effects have been …
Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson's disease
Braak's prion-like theory fundamentally subverts the understanding of Parkinson's disease
(PD). Emerging evidence shows that pathologic α-synuclein (α-syn) is a prion-like protein …
(PD). Emerging evidence shows that pathologic α-synuclein (α-syn) is a prion-like protein …
[HTML][HTML] The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy
TE Moors, CA Maat, D Niedieker, D Mona… - Acta …, 2021 - Springer
Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …
[HTML][HTML] Structural and functional insights into α-synuclein fibril polymorphism
Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
[HTML][HTML] Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
NP Marotta, J Ara, N Uemura, MG Lougee… - Acta neuropathologica …, 2021 - Springer
Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological
features of many neurodegenerative diseases. They consist largely of aggregated forms of …
features of many neurodegenerative diseases. They consist largely of aggregated forms of …
[HTML][HTML] Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases
Z Tanei, Y Saito, S Ito, T Matsubara, A Motoda… - Acta …, 2021 - Springer
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders
characterized by the wide distribution of Lewy bodies and neurites in the central and …
characterized by the wide distribution of Lewy bodies and neurites in the central and …
[HTML][HTML] Alpha-synuclein post-translational modifications: implications for pathogenesis of lewy body disorders
NO Manzanza, L Sedlackova… - Frontiers in aging …, 2021 - frontiersin.org
Lewy Body Disorders (LBDs) lie within the spectrum of age-related neurodegenerative
diseases now frequently categorized as the synucleinopathies. LBDs are considered to be …
diseases now frequently categorized as the synucleinopathies. LBDs are considered to be …