[HTML][HTML] White adipose tissue dysfunction in obesity and aging
M Reyes-Farias, J Fos-Domenech, D Serra… - Biochemical …, 2021 - Elsevier
Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …
[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm
D Gems, JP De Magalhães - Ageing research reviews, 2021 - Elsevier
With the goal of representing common denominators of aging in different organisms López-
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …
Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …
physiologic state of the organism in health and disease. Additionally, specific metabolites …
The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan
R Buffenstein, W Craft - The extraordinary biology of the naked mole-rat, 2021 - Springer
The subterranean-dwelling naked mole-rat (Heterocephalus glaber) is an extremophilic
rodent, able to thrive in the harsh underground conditions of sub-Saharan Northeast Africa …
rodent, able to thrive in the harsh underground conditions of sub-Saharan Northeast Africa …
The antagonistic pleiotropy of insulin‐like growth factor 1
WB Zhang, K Ye, N Barzilai, S Milman - Aging Cell, 2021 - Wiley Online Library
While insulin‐like growth factor‐1 (IGF‐1) is a well‐established modulator of aging and
longevity in model organisms, its role in humans has been controversial. In this study, we …
longevity in model organisms, its role in humans has been controversial. In this study, we …
Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models
S Anoar, NS Woodling, T Niccoli - Frontiers in Neuroscience, 2021 - frontiersin.org
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …
Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity
JW Millington, GP Brownrigg, C Chao, Z Sun… - Elife, 2021 - elifesciences.org
Nutrient-dependent body size plasticity differs between the sexes in most species, including
mammals. Previous work in Drosophila showed that body size plasticity was higher in …
mammals. Previous work in Drosophila showed that body size plasticity was higher in …
Repurposing drugs to fight aging: The difficult path from bench to bedside
A Vaiserman, A Koliada, O Lushchak… - Medicinal Research …, 2021 - Wiley Online Library
The steady rise in life expectancy occurred across all developed countries during the last
century. This demographic trend is, however, not accompanied by the same healthspan …
century. This demographic trend is, however, not accompanied by the same healthspan …
Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model …
T Ochiai, T Sano, T Nagayama, N Kubota… - Neurobiology of …, 2021 - Elsevier
Insulin signaling has been implicated in the metabolism as well as aging and longevity.
Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated …
Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated …