Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

With the goal of representing common denominators of aging in different organisms López-
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …

The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

The subterranean-dwelling naked mole-rat (Heterocephalus glaber) is an extremophilic
rodent, able to thrive in the harsh underground conditions of sub-Saharan Northeast Africa …

While insulin‐like growth factor‐1 (IGF‐1) is a well‐established modulator of aging and
longevity in model organisms, its role in humans has been controversial. In this study, we …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …

Nutrient-dependent body size plasticity differs between the sexes in most species, including
mammals. Previous work in Drosophila showed that body size plasticity was higher in …

The steady rise in life expectancy occurred across all developed countries during the last
century. This demographic trend is, however, not accompanied by the same healthspan …

Insulin signaling has been implicated in the metabolism as well as aging and longevity.
Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated …