Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

The largest subtype of breast cancer is characterized by the expression and activity of the
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …

Abstract Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic
developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and …

Differentiation of naïve peripheral B cells into terminally differentiated plasma cells is
characterized by epigenetic alterations, yet the epigenetic mechanisms that control B‐cell …

RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family,
which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 …

Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and
regenerating adult tissues. In addition to having the capacity to generate all the differentiated …

BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that
regulates gene expression and other cellular processes, via deubiquitination of histone …

Polycomb repressive complexes (PRCs) are a heterogenous collection of dozens, if not
hundreds, of protein complexes composed of various combinations of subunits. PRCs are …

RUNX1 is a transcription factor that plays key roles in hematopoietic development and in
hematopoiesis and lymphopoiesis. In this article, we report that RUNX1 regulates a gene …

Background Polycomb repressive complex 1 (PRC1) and PRC2 are chromatin regulators
maintaining transcriptional repression. The deposition of H3 lysine 27 tri-methylation …